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Cytologic atypia in a 53-year-old man with finasteride-induced gynecomastia

, : Cytologic atypia in a 53-year-old man with finasteride-induced gynecomastia. Archives of Pathology & Laboratory Medicine 124(4): 625-627

Finasteride has been associated with the development of gynecomastia. Although cytoplasmic vacuolization has been noted in prostatic epithelium in men taking this drug, we found no documentation of the cytologic changes in finasteride-associated gynecomastia. We present the case of a 53-year-old man who developed unilateral gynecomastia following finasteride therapy for alopecia. A fine-needle aspiration biopsy of the mass was diagnosed as adenocarcinoma on the basis of nuclear atypia and particularly because of cytoplasmic vacuolization. Subsequent excisional biopsy revealed benign gynecomastia with no evidence of malignant change. The ductal epithelium did exhibit cytoplasmic vacuolization similar to that described in the prostate following finasteride therapy. We believe this is the first reported case documenting the cytologic changes seen in gynecomastia secondary to finasteride therapy. Cytoplasmic vacuolization in this setting should not be considered evidence of malignancy in men with gynecomastia. As with gynecomastia in general, extreme caution should be used before rendering a cytologic diagnosis of malignancy.


PMID: 10747325

DOI: 10.1043/0003-9985(2000)124<0625:CAIAYO>2.0.CO;2

Other references

Kayal J.R.; D.R.ena, 1991: Microseismicity and tectonics in Northeast India. Bulletin of the Seismological Society of America 81(1): 131-138

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Graczyk, R., 1978: Theoretical elements of a reintroduction of endangered species of mammals. Congressus Theriologicus Internationalis, 2: 154

Rajagopal G.; Ramesh N.; Ramakrishnan S., 1981: Effect of acute ethylene glycol toxicity on blood ammonia and brain amino acids in male albino rats. Acute effects of ethylene glycol (EG) were observed in male albino rats, fed orally 10 ml/kg from a 50% aqueous solution of EG. A fall in urinary pH, blood pH and plasma bicarbonate showed metabolic acidosis. Ammonia secreted by the distal tubular...

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Papa, A., 1950: Case of hepatic tuberculoma in the course of a periduodenitis syndrome. Athena; Rassegna Mensile di Biologia, Clinica E Terapia 16(7-8): 163-165

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Vacquier, V.D., 1981: Dynamic changes of the egg cortex. This review of work on changes occurring between meiosis and early cleavage is concerned chiefly with the sea urchin, but includes occasional references to species falling within the scope of ABA, e.g. Penaeus and the hamster.