geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cytologic features useful for distinguishing small cell from non-small cell carcinoma in bronchial brush and wash specimens


, : Cytologic features useful for distinguishing small cell from non-small cell carcinoma in bronchial brush and wash specimens. American Journal of Clinical Pathology 114(2): 197-202

One blinded observer (C.D.S.) retrospectively reviewed 76 previously diagnosed and biopsy-confirmed malignant bronchial brush and wash specimens, 46 non-small cell and 30 small cell carcinomas, obtained from 55 patients. Each case was scored for the presence or absence of 36 standard criteria (architectural, cytoplasmic, and nuclear). Logistic regression analysis was used to determine which criteria were most useful for separating small cell from non-small cell lesions. Although no single criterion displayed 100% sensitivity and specificity for small cell cancer, univariate statistical analysis indicated that 3 individual criteria (nuclear molding, finely granular or "salt and pepper" chromatin, and scant delicate cytoplasm) were more than 90% sensitive and specific in cases of small cell carcinoma. The presence of nuclear molding alone provided the best fit for the logistic regression model. When nuclear molding was present, the odds of a small cell diagnosis increased more than 300-fold. Nuclear molding, finely granular or salt and pepper chromatin, and scant, delicate cytoplasm are the 3 most sensitive and specific cytomorphologic features traditionally used to separate small cell from non-small cell carcinoma. Nuclear molding alone represents the most significant cytomorphologic feature for distinguishing between these malignant lesions.

US$19.90

PMID: 10941334

DOI: 10.1309/8MQG-6XEK-3X9L-A9XU


Other references

Bickley, R.; Vygotskii, L.S., 1977: Vygotsky's contributions to a dialectical materialist psychology. Science and Society 41(2): 191-207

Peralta, C.A.; Adeney, K.L.; Shlipak, M.G.; Jacobs, D.; Duprez, D.; Bluemke, D.; Polak, J.; Psaty, B.; Kestenbaum, B.R., 2010: Structural and functional vascular alterations and incident hypertension in normotensive adults: the Multi-Ethnic Study of Atherosclerosis. Vascular abnormalities may exist before clinical hypertension. Using Poisson regression, the authors studied the association of coronary artery calcium (CAC), common carotid intima-media thickness (CIMT), aortic distensibility, and large and small...

L.Aiguo, 1997: Application of a mathematical model for stimulating the water-rock interaction during the thermal recovery of heavy petroleum. During the thermal recovery of heavy petroleum, the injected substances will cause strong water-rock interaction because of the high temperature environment of the reservoir. This will also affect the injected substances to undergo obvious physica...

Jensen, C.L.; Chen, H.; Fraley, J.K.; Anderson, R.E.; Heird, W.C., 1996: Biochemical effects of dietary linoleic/alpha-linolenic acid ratio in term infants. Recent statements concerning linoleic (LA) and alpha-linolenic acid (LNA) intakes for infants include a desirable range of LA/LNA ratios. To evaluate several dietary LA/LNA ratios, the fatty acid patterns of plasma and erythrocyte phospholipid fra...

Andhariya, J.V.; Burgess, D.J., 2016: Recent advances in testing of microsphere drug delivery systems. This review discusses advances in the field of microsphere testing. In vitro release-testing methods such as sample and separate, dialysis membrane sacs and USP apparatus IV have been used for microspheres. Based on comparisons of these methods, U...

B.A.T., 1983: Phloem in the haustorium of striga gesnerioides a parasitic scrophulariaceae. The lack of phloem in the haustorium is a common trait of parasitic phanerogams, a few species excepted. Observations using the EM and fluorescence microscope confirm this characteristic in the haustorium of Striga hermonthica. But sieve tube elem...

Barman, B.; Bhattacharyya, S.N., 2016: mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA (miRNA)-mediated Translation Repression in Mammalian Cells. MicroRNA (miRNA) binds to the 3'-UTR of its target mRNAs to repress protein synthesis. Extensive research was done to understand the mechanism of miRNA-mediated repression in animal cells. Considering the progress in understanding the mechani...

Cassin, P.J.; Lossois, P., 1978: Method of nucellar selection used in Corsica. Seeds of 22 mandarin, 12 orange, 3 lemon, 1 tangelo and 2 grapefruit cvs from different countries but mainly North Africa were planted in 1962 and 1963. Buds from the seedlings were grafted on trifoliate orange and Troyer citrange in 1964 and 1965...

Kavoliunaite, I.; Paliulyte, E., 2004: Investigation of growth dynamics. The growth and development of Elytrigia repens [Elymus repens] in various agrophytocenoses (plots with winter rye, potato, spring barley, undersown spring barley or one-year-old perennial grasses; bare fallow; and untilled soil) were studied durin...

Sinnott, C.; Byrne, M.; Bradley, C.P., 2017: Improving medication management for patients with multimorbidity in primary care: a qualitative feasibility study of the MY COMRADE implementation intervention. For the majority of patients with multimorbidity, the prescription of multiple long-term medications (polypharmacy) is indicated. However, polypharmacy poses a risk of adverse drug events, drug interactions and excessive treatment burdens. To help...