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Daily dosing versus alternate-day dosing of simvastatin in patients with hypercholesterolemia

, : Daily dosing versus alternate-day dosing of simvastatin in patients with hypercholesterolemia. Pharmacotherapy 22(9): 1110-1116, September

Study Objective: To compare the efficacy of daily simvastatin administration with that of alternate-day therapy at double the daily dose. Design: Nonrandomized, before-after comparison trial. Setting: Outpatient clinic of a Veterans Affairs medical center. Patients: Fifteen men with hyperlipidemia. Intervention: The simvastatin regimen for patients with a low-density lipoprotein cholesterol (LDL) level at their established National Cholesterol Education Program goal was converted from daily dosing to double the daily dose given every other day for 8 weeks. Measurements and Main Results: Baseline laboratory values were obtained for patients receiving daily simvastatin therapy. After 8 weeks of alternate-day therapy, follow-up laboratory values were obtained and assessed for efficacy and toxicity. The LDL-lowering effect of the daily dosing regimen was compared with that of the alternate-day dosing regimen. Paired t tests were computed to compare LDL concentrations before and after the study using a 95% confidence interval. No statistically significant difference was observed. Conclusion: Alternate-day dosing of simvastatin may be an effective alternative to daily dosing.


PMID: 12222546

DOI: 10.1592/phco.22.13.1110.33518

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