+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Decline of hepatitis B carrier rate in vaccinated and unvaccinated subjects: sixteen years after newborn vaccination program in Taiwan

, : Decline of hepatitis B carrier rate in vaccinated and unvaccinated subjects: sixteen years after newborn vaccination program in Taiwan. Journal of Medical Virology 69(4): 471-474

Taiwan was an endemic area for hepatitis B virus (HBV) infection, and related liver diseases cause a significant drain of public resources. To control the endemic, a nation-wide newborn vaccination program was started in 1985. We reviewed the results of the annual survey for HBV surface antigen (HBsAg) performed in freshmen class of two high schools in Hualien, eastern Taiwan, from 1991 to 2001. A total of 10,194 students, most of them 15 years old, were tested for serum HBsAg using enzyme immunoassays. There is a significant trend (P < 0.0001) of decreasing HBsAg carrier rate from 20.3 to 4.4% in males and 14.3% to 2.4% in females, respectively, over 11 years. The HBsAg carrier rate was 16.0-20.3% in students surveyed during 1991-1993 (born more than 6 years before the start of the national vaccination program), which decreased to 7.7-11.9% during 1994-1999 (born 1-6 years before the program). It further declined to 4.7% and 3.4% in 2000 and 2001 (born after the start of the program). The HBsAg carrier rate in male students was significantly higher than that in female students in most of the years. The HBV newborn vaccination program not only successfully prevented most of the perinatal transmission of HBV but also reduced horizontal transmission of HBV to children born up to 6 years before the start of the program. Also, the protection persisted for at least 15 years.


PMID: 12601753

DOI: 10.1002/jmv.10333

Other references

Borlaug, B.A.; Olson, T.P.; Lam, C.S.P.; Flood, K.S.; Lerman, A.; Johnson, B.D.; Redfield, M.M., 2010: Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. The purpose of this study was to comprehensively examine cardiovascular reserve function with exercise in patients with heart failure and preserved ejection fraction (HFpEF). Optimal exercise performance requires an integrated physiologic response...

Purschke, H., 1956: Will the treatment with anticoagulants reduce mortality for postoperative embolism?. Zentralblatt für Chirurgie 81(29): 1213-1218

Heijink, I.H.; Van Oosterhout, A.J.M., 2005: Targeting T cells for asthma. The type 2 T-helper (Th2) lymphocyte can be regarded as an important target cell for the treatment of allergic asthma as it plays a crucial role in the initiation, progression and persistence of disease. Several strategies to target Th2 cells can...

Cascio, M.; Pygon, B.; Bernett, C.; Ramanathan, S., 1997: Labour analgesia with intrathecal fentanyl decreases maternal stress. Purpose: Lumbar epidural analgesia (LEA) decreases maternal stress as measured by maternal circulating plasma catecholamine concentrations. Intrathecal fentanyl (ITF) provides effective labour analgesia but its effect on maternal epinephrine (Epi)...

Milbocker, D.C., 1988: Ventilated high humidity propagation. A humidifier was designed at Hampton Roads by 1983 and after 4 years of testing was introduced commercially as the Humidifan. It is portable, easy to set up, can be operated by nurserymen and satisfies the requirements for ventilated high humidity...

Zhang, Y.; Shen, T-Ting.; Zhang, H-Li.; Kirillov, A.M.; Cai, H-Juan.; Wu, J.; Liu, W-Sheng.; Tang, Y., 2016: A multifunctional nanocomposite for luminescence resonance energy transfer-guided synergistic monitoring and therapy under single near infrared light. By utilizing a drug coordinated to Eu(3+) as a blocker of luminescence resonance energy transfer from the Eu(3+) complex to gold nanotriangles, we successfully implemented multiple functions into one nanocomposite; it operates under single near in...

Maksimov, G.B.; Medvedev, S.S., 1979: Mechanism of kinetin action on functional activity of roots. The activating effect of kinetin (1 x 10-6M) on K absorption by roots of maize seedlings was accompanied by increased respiration rate, changes in electrophysiological parameters and increased activity of K+-stimulated ATPase. It was suggested tha...

Benesova Z.; Cadek J., 1979: Conditions of the origin of the Moldava fluorite deposit. Vestnik Ustredniho Ustavu Geologickeho = Bulletin of the Geological Survey, Prague 54(3): 151-160

Doumy, G.; Roedig, C.; Son, S-K.; Blaga, C.I.; DiChiara, A.D.; Santra, R.; Berrah, N.; Bostedt, C.; Bozek, J.D.; Bucksbaum, P.H.; Cryan, J.P.; Fang, L.; Ghimire, S.; Glownia, J.M.; Hoener, M.; Kanter, E.P.; Krässig, B.; Kuebel, M.; Messerschmidt, M.; Paulus, G.G.; Reis, D.A.; Rohringer, N.; Young, L.; Agostini, P.; DiMauro, L.F., 2011: Nonlinear atomic response to intense ultrashort x rays. The nonlinear absorption mechanisms of neon atoms to intense, femtosecond kilovolt x rays are investigated. The production of Ne(9+) is observed at x-ray frequencies below the Ne(8+), 1s(2) absorption edge and demonstrates a clear quadratic depend...

Businco, L.; Bruno, G.; Giampietro, P.G.anni; Furcolo, G.; Antoniazzi, F., 1999: Absence of oestrogen hormonal effects in long-term soy formula fed children. Pediatric Research 45(4 PART 2): 8A, April