geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Delayed healing of acetic-acid-induced gastric ulcer in portal hypertensive rats


, : Delayed healing of acetic-acid-induced gastric ulcer in portal hypertensive rats. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes 31(4): 340-346

The aim of the present study was to determine the effect of portal hypertension on the healing of gastric ulcers in rats. Portal hypertension was induced by staged portal vein ligation. Sham-operated (SO) rats served as controls. Gastric ulcers were induced by application of acetic acid to the serosal surface of the stomach. Healing was assessed by determining the ulcer area on days 3, 7, and 10 after ulcer induction. Epithelial proliferation at the ulcer margin was assessed by evaluating the proliferating cell nuclear antigen labeling index. On days 3 and 7, the proliferating cell nuclear antigen labeling index was lower in portal hypertensive (PHT) rats than in SO rats. On day 10, the ulcer area in PHT rats was nearly twice that in SO rats (4.13 +/- 0.29 vs. 2.28 +/- 0.22 mm(2), p < 0.05). These results suggest that portal hypertension may delay gastric ulcer healing. Furthermore, the inhibition of epithelial proliferation at the ulcer margin may be involved in the delayed healing in portal hypertension.

US$19.90

PMID: 10449993

DOI: 8711


Other references

Takahashi, T.; Yoshikawa, N., 2008: Analysis of cell-to-cell and long-distance movement of apple latent spherical virus in infected plants using green, cyan, and yellow fluorescent proteins. Apple latent spherical virus (ALSV) expressing green, cyan, and yellow fluorescent proteins (GFP, CFP, and YFP) was constructed and used to analyze the local and systemic movement of the virus in infected plants. In Chenopodium quinoa plants inocu...

Schiltenwolf, M.; Ewerbeck, V., 2004: Introduction to the topic: Pain therapy. New knowledge alters orthopedic management strategies. Der Orthopade 33(5): 507-507

Kazmi, S.H.; Naglik, J.R.; Sweet, S.P.; Evans, R.W.; O'Shea, S.; Banatvala, J.E.; Challacombe, S.J., 2006: Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids. Several human mucosal fluids are known to possess an innate ability to inhibit human immunodeficiency virus type 1 (HIV-1) infection and replication in vitro. This study compared the HIV-1 inhibitory activities of several mucosal fluids, whole, su...

Ormori D.M.; Simmons J.O.; Kroenke K.; Wood D.R.; Meier N.J., 1988: Does phenylpropanolamine affect blood pressure in mildly hypertensive patients. Clinical Research 36(3): 747A

Karlowsky, J.A.; Master, R.N.; Kelly, L.J.; Thornsberry, C.; Jones, M.E.; Sahm, D.F., 2002: Impact of test method on differences in cefepime and ceftazidime resistance in gram-negative bacilli. Background: Perceived differences in the activities of cefepime (CFP) and ceftazidime (CTZ) against P. aeruginosa (PA) have been reported for isolates tested using different antimicrobial susceptibility testing methods (TMs). The current study det...

Panagiotopoulou-Karatagli, A.T.ekos, I.K.rataglis, S., 1974: Temperature and osmotic resistance of sea algae of the Thes saloniki Gulf, Greece. Botanica marina: 17 (2) 118-123

Nelson, N., 1988: Mutual reinforcement between epidemiology and the laboratory in the study of environmental cancer. Annals of the New York Academy of Sciences 534: 1021-1028

Bates Robert L., 1984: Glass; a solid liquid. Earth Science 37(3): 22-23

Cebi, N.; Walterbusch, G., 2008: Single proximal anastomosis for multiple vein coronary artery bypasses in diseased ascending aorta. Minimization of the manipulation of the diseased ascending aorta has been shown to be associated with a reduced risk of postoperative stroke during coronary artery bypass surgery. We describe in this paper a novel method in which a single proximal...

Wang, Q.; Wyman, D.A.; Xu, J.; Wan, Y.; Li, C.; Zi, F.; Jiang, Z.; Qiu, H.; Chu, Z.; Zhao, Z.; Dong, Y., 2008: Triassic Nb-enriched basalts, magnesian andesites, and adakites of the Qiangtang Terrane central Tibet; evidence for metasomatism by slab-derived melts in the mantle wedge. Chronological, geochemical, and isotopic data are given for Triassic (219-236 Ma) adakite-magnesian andesite-Nb-enriched basaltic rock associations from the Tuotuohe area, central Qiangtang terrain. The adakites and magnesian andesites are charact...