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Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons

, : Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. Journal of Biological Chemistry 277(28): 25400-7

We have identified a novel epidermal growth factor (EGF)-like repeat-containing single-pass transmembrane protein that is specifically expressed in the developing and mature central nervous system. Sequence analysis revealed that the 10 EGF-like repeats in the extracellular domain are closely related to those of the developmentally important receptor Notch and its ligand Delta. We thus named the molecule Delta/Notch-like EGF-related receptor (DNER). DNER protein is strongly expressed in several types of post-mitotic neurons, including cortical and hippocampal pyramidal neurons, cerebellar granule cells, and Purkinje cells. DNER protein is localized to the dendritic plasma membrane and endosomes and is excluded from the axons, even when overexpressed. The tyrosine-based sorting motif in the cytoplasmic domain is required for dendritic targeting of DNER. Direct in vivo binding of DNER to the coat-associated protein complex AP-1 strongly suggests that DNER undergoes AP-1-dependent sorting to the somatodendritic compartments from the trans-Golgi network and subsequent passage through the endosomal system.


PMID: 11950833

DOI: 10.1074/jbc.M110793200

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Michels, K.; Cromme, N.; Glatzle, A.; Schultze Kraft, R., 2001: Biological control of leaf-cutting ants using forage grasses: Nest characteristics and fungus growth. One of the major pasture pests in the neotropics is the leaf-cutting ant Acromyrmex landolti, which cuts monocots to nourish a symbiotic fungus as a food source. The objective of the present study was to characterize ant nests and to test the effe...

Hart, L.; Saettler, A., 1981: White mold of beans Sclerotinia sclerotiorum. Extension bulletin E Cooperative Extension Service Michigan State University: 981 (892)

Siegl, H., 1968: Scintigraphy of the neck lymphatic pathways after "neck dissection". (Preliminary results). Monatsschrift für Ohrenheilkunde und Laryngo-Rhinologie 102(4): 262-268

Ng, M.Ying.; Wang, M.; Casey, P.J.; Gan, Y-Hwen.; Hagen, T., 2017: Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). Cycle inhibiting factors (Cifs) are virulence proteins secreted by the type III secretion system of some Gram-negative pathogenic bacteria including Burkholderia pseudomallei. Cif is known to function to deamidate Nedd8, leading to inhibition of C...

Matz, M.; Link, H.; Nicklisch, F., 1984: Risk of epididymitis following transurethral and transvesical bladder neck surgery. Epididymitis after operations on the vesical cervix is of canicular or lymphohaematogenous origin. The latter form is at present not absolutely avoidable. For aetiological reasons TUR has a clearly greater effect as a method of vasoresective proph...

Alhava, E.; Klinge, E., 1972: Age and brain catecholamine content as factors influencing amphetamine toxicity in mice. Acta Pharmacologica et Toxicologica 31(5): 401-411

Lawson E.W.; Parthasarathy M.V., 1989: Microfilaments in the laticifers of cryptostegia grandiflora rbr asclepiadaceae. American Journal of Botany 76(6 SUPPL): 43

E.B.üggemann; H.G.rwig; Th. Gnauk; K.M.ller; H.H.rrmann, 2009: Influence of seasons, air mass origin and day of the week on size-segregated chemical composition of aerosol particles at a kerbside. The size-segregated chemical composition of atmospheric aerosol particles (aerodynamic diameter Dpaer = 0.05–10 m) was studied to reveal differences between seasons (winter/summer), air mass origins (East/West/North), and days...

Teller, R.; Beigelman, P., 1961: Effects of various amino acids upon glucose uptake of rat epididymal adipose tissue. At concentrations of 10-2[long dash]10-3[image], 6 L-amino acids, arginine, glutamic acid, histidine, leucine, lysine, and tyrosine, demonstrated significant inhibition of glucose uptake by adiposetissue. L-isoleucine and L-proline, at 10-3 [image...

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