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Dermal exposure assessment of polycyclic aromatic hydrocarbons: In vitro percutaneous penetration from lubricating oil


, : Dermal exposure assessment of polycyclic aromatic hydrocarbons: In vitro percutaneous penetration from lubricating oil. International Archives of Occupational & Environmental Health 72(8): 528-532, Nov

Objectives: Percutaneous penetration of polycyclic aromatic hydrocarbons (PAHs) is affected by various factors connected to exposure conditions. The nature of the matrix, such as that of oil, can strongly affect their percutaneous penetration. Risk assessment should consider these effects. We examined the effect of matrix on percutaneous penetration of PAHs, particularly that of lubricating oil. Methods: The test apparatus consisted of an in vitro static diffusion cell system using full-thickness monkey (Cercopithecus aetiops) skin as the membrane and saline solution with gentamycin sulfate and 4% bovine serum albumin as receptor fluid. Chemical analysis of PAHs in the samples obtained from cells was carried out by inverse-phase HPCL, and the results were read by spectrofluorimetry. Results: Comparing the penetration of 13 PAHs from a lubricating oil and from acetone solution with artificial sweat resulted in a significantly slower passage from the oil matrix for acenaphthene, anthracene, phenanthrene, fluoranthene, naphthalene, pyrene, fluorene (Mann-Whitney U test, P < 0.05). No significant differences in the passage were found for chrysene because, in the test with oil, its concentration was very often below the detection limit. For benzo(a)anthracene, benzo(b)fluoranthene, benzo(k)fluoranthene, and benzo(a)pyrene it was possible to demonstrate a passage through the skin only when compounds were applied in acetone solution with artificial sweat. Conclusions: The results of the study suggest the necessity of dermal penetration data relevant for risk assessment, obtained under experimental conditions similar to the real exposure conditions.

US$19.90

PMID: 10592005

DOI: 10.1007/s004200050411


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Sakurai, T.; Serizawa, S.; Isobe, T.; Kobayashi, J.; Kodama, K.; Kume, G.; Lee, J-Hoon.; Maki, H.; Imaizumi, Y.; Suzuki, N.; Horiguchi, T.; Morita, M.; Shiraishi, H., 2010: Spatial, phase, and temporal distributions of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in Tokyo Bay, Japan. The spatial distribution, partitioning, and time trends of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) were investigated in the water column and bottom sediment of Tokyo Bay, Japan, during 2004-2006. A total of 480 water and 60...

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Krudysz, J., 1970: Rehabilitation in retinal detachment. Klinika Oczna 40(2): 279-283

Stewart, H.F., 1962: Repression: experimental studies since 1943. Psychoanalysis and the Psychoanalytic Review 49: 93-99

Banks, C.S., 1919: Phlebotomus nicnic, a New Species, the first Philippine Record for this Genus. Phlebotomus nicnic, sp. n., is here described for the first time, though its existence has been known for a number of years in the Philippines. It bites mainly at night, and is probably a disease transmitter. It is believed to breed in kitchen dra...

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