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Detecting structural changes in whole brain based on nonlinear deformations-application to schizophrenia research


, : Detecting structural changes in whole brain based on nonlinear deformations-application to schizophrenia research. Neuroimage 10(2): 107-113

This paper describes a new method for detecting structural brain differences based on the analysis of deformation fields. Deformations are obtained by an intensity-based nonlinear registration routine that transforms one brain onto another one. We present a general multivariate statistical approach to analyze deformation fields in different subjects. This method was applied to the brains of 85 schizophrenic patients and 75 healthy volunteers to examine whether low frequency deformations are sufficiently sensitive to detect regional deviations in the brains of both groups. We observed significant changes caused by volume reduction in brains of schizophrenics bilaterally in the thalamus and in the superior temporal gyrus. On the left side, the superior frontal gyrus and precentral gyrus are found to be changed, while on the right side, the middle frontal gyrus was altered. In addition, there were significant changes in the occipital lobe (left lingual gyrus) and in the left cerebellum. Volume enlargement in brains of schizophrenics was observed in the right putamen and in the adjacent white matter of the thalamic region. Our data suggest a disturbance in the nodes of a prefrontal-thalamic-cerebellar circuitry. This provides further support for the model of "cognitive dysmetria," which postulates a disruption in these nodes. We have demonstrated the application of deformation-based morphometry by detecting structural changes in the whole brain. This technique is fully automatic, thus allowing for the inclusion of large samples, with no user bias or a priori-defined regions of interest.

US$19.90

PMID: 10417245

DOI: 10.1006/nimg.1999.0458


Other references

Chaudhary, D.R., 1999: Components of genetic variation in yield traits of brinjal (Solanum melongena L.). Components of genetic variation for eleven quantitative characters were studied in an eight parental half diallel of brinjal [aubergine] (Solanum melongena). The 8 genetically diverse genotypes studied were Arka Nidhi, Pusa Purple Cluster, SM6-6,...

Soler, M.; Camacho, M.; Molins-Pujol, A.M.; Vila, L., 2000: Effect of an imidazolineoxyl nitric oxide on prostaglandin synthesis in experimental shock: possible role of nitrogen dioxide in prostacyclin synthase inactivation. The effect of 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), a nitric oxide (NO) scavenger that yields nitrogen dioxide (NO(2)) in a rat endotoxemia model was investigated. Endotoxin (lipopolysaccharide [LPS]) increased...

Bock, E.; Weeke, B.; Rafaelsen, O.J., 1971: Serum proteins in acutely psychotic patients. Journal of Psychiatric Research 9(1): 1-9

Sunita, M.; Padmaja, M.; Anupama, B.; Kumari, C.Gyana., 2012: Synthesis, characterization, DNA binding and cleavage studies of mixed-ligand Cu(II) complexes of 2,6-bis(benzimidazol-2-yl)pyridine. Four novel copper(II) complexes of the composition [CuLX] where L = 2,6-bis(benzimidazole-2yl)pyridine, X = dipyridophenazine (L1), 1,10-phenanthroline (L2), hydroxyproline (L3) and 2,6-pyridine dicarboxylic acid (L4) were synthesized and characte...

Hukku, S.; Fernandes, P.; Vasishta, S.; Sharma, V.K., 1989: Radiation therapy alone and in combination with bleomycin and 5-fluorouracil in advanced carcinoma esophagus. This presentation is a randomized prospective study of 74 patients of squamous cell carcinoma of esophagus divided into two groups. First group was treated with radical radiation alone and the other with radical radiation and combination of bleomy...

Turner, T.F.; Collyer, M.L.; Krabbenhoft, T.J., 2010: A general hypothesis-testing framework for stable isotope ratios in ecological studies. We propose a framework for hypothesis-testing of stable isotope ratios in ecological studies. Statistical procedures are based on analysis of nested linear models and a residual permutation procedure (RPP) that is employed to evaluate probabilitie...

Duffy C.M.; Arsenault L.; Watanabe Duffy K.N., 1991: Measuring quality of life in chronic childhood arthritis are parents accurate informants?. Arthritis & Rheumatism 34(9 SUPPL): S81

Anonymous, 2006: Multicentre study on peri- and postoperative central venous oxygen saturation in high-risk surgical patients. Low central venous oxygen saturation (ScvO2) has been associated with increased risk of postoperative complications in high-risk surgery. Whether this association is centre-specific or more generalisable is not known. The aim of this study was to...

Fracasso, R.P.; Hoffman, F.J.; Roder, H.M., 1994: NGF-stimulation of ERKs in undifferentiated PC12 cells does not lead to PHF-type tau-hyperphosphorylation. Neurobiology of Aging 15(SUPPL 1): S26-S27

Valvassori, G.E.; Buckingham, R.A., 1995: Conventional radiography. Valvassori, G E [Author], Mafee, M F [Author], Carter, B L [Author] Imaging of the head and neck 2-3