geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Development and application of a generalized physiologically based pharmacokinetic model for multiple environmental contaminants


, : Development and application of a generalized physiologically based pharmacokinetic model for multiple environmental contaminants. Environmental Toxicology & Chemistry 22(1): 26-34, January

The pharmacological disposition of four environmental contaminants resulting from acute and chronic exposure regimes is simulated using a general physiologically based pharmacological (PBPK) model. The model, which is detailed in supporting materials, is mechanistic in structure and relies on available physical-chemical partitioning and reactivity data, but experimental partitioning and absorption efficiency data can be used to refine the parameters. It is designed to complement environmental fate models, thus linking chemical emission rates with environmental and physiological behavior as part of the larger environmental risk assessment process. The model is illustratively applied to inhaled styrene and trichloroethene as well as ingested dibutyl phthalate and di(2-ethylhexyl) phthalate. The phthalate simulations include the corresponding monoester and conjugated monoester as metabolites. Tissue concentrations for each of the chemicals and metabolites are simulated for acute, occupational, and environmental exposure regimes. The same model is used for all chemicals and exposure regimes with only the physical-chemical properties, reaction rates, and exposure estimates being changed.

US$19.90

DOI: 10.1002/etc.5620220104


Other references

Chang, H.; Zhang, T.; Zhang, Z.; Bao, R.; Fu, C.; Wang, Z.; Bao, Y.; Li, Y.; Wu, L.; Zheng, X.; Wu, J., 2012: Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects. This study compares the density and tissue-specific distribution of 5-methyl cytosine (5mC) in genomic DNA from human fetuses with or without neural tube defects (NTD) and examines whether low maternal serum folate is a possible correlate and/or r...

Cislaghi, C.; Buiatti, E., 2001: Appeal to the Minister for the autonomy of the Agency for Public Health of the Lazio region. Epidemiologia E Prevenzione 25(1): 3-3

Stapleton, F.; Stretton, S.; Papas, E.; Skotnitsky, C.; Sweeney, D.F., 2006: Silicone hydrogel contact lenses and the ocular surface. For 30 years, contact lens research focused on the need for highly oxygen-permeable (Dk) soft lens materials. High Dk silicone hydrogel contact lenses, made available in 1999, met this need. The purpose of this review is to examine how silicone hy...

Lachanas, V.A.; Hajiioannou, J.K.; Karatzias, G.T.; Filios, D.; Koutsias, S.; Mourgelas, C., 2007: Comparison of LigaSure vessel sealing system, harmonic scalpel, and cold knife tonsillectomy. We sought to compare LigaSure Vessel Sealing System tonsillectomy (LT), Harmonic Scalpel tonsillectomy (HST), and cold knife tonsillectomy (CKT). We conducted a prospective study on 161 adult patients undergoing tonsillectomy. Subjects were random...

Bath, G.F.; Wentzel, D.; van Tonder, E.M., 1979: Cretinism in Angora goats. Angora goats at a farm in the Graaff-Reinet district of South Africa had been bought 2 years previously. Their young of the 1st year had had no goitre. There had been no goitre on the farm during the many years with the present owner, and there ha...

Zink, R.; Klaenhammer, T.R., 1997: Lactobacillus species, deficient in S-layers, possess highly conserved slp-core gene regions. Abstracts of the General Meeting of the American Society for Microbiology 97(0): 340

Güngör, O.; Özkaya, A.Kağan.; Şahin, Y.; Güngör, Gülay.; Dilber, C.; Aydın, Kürşad., 2016: A compound heterozygous EARS2 mutation associated with mild leukoencephalopathy with thalamus and brainstem involvement and high lactate (LTBL). Mitochondrial glutamyl-tRNA synthetase is a major component of protein biosynthesis that loads tRNAs with cognate amino acids. Mutations in the gene encoding this enzyme have been associated with a variety of disorders related to oxidative phospho...

Bösze, P.; Kovács, Z.; Artner, A.; László, J., 1990: CA 125 levels in patients with hypoestrogenic ovarian failure. The source of CA 125 in the sera of women is not known. Serum CA 125 concentrations were measured in 36 women with hypoestrogenic ovarian failure of whom 30 had hyper-(group A), 6 had hypo- or normogonado-tropic amenorrhea (group B). Group A consi...

Heinl, S.; Grabherr, R., 2017: Systems biology of robustness and flexibility: Lactobacillus buchneri-A show case. Lactobacillus buchneri is a lactic acid bacterium that naturally inhabits very different ecological niches and plays an ambivalent role in many food and feed fermentation processes, where it can act as useful starter or as spoilage organism. Due t...

Smith, N.; Johnson, F.J., 2006: Effects of inhaled eotaxin on airway function and inflammatory cell influx in sensitised and non-sensitised guinea pigs. Eotaxin is a chemokine that has high potency and selectivity as a chemoattractant agent for eosinophils, signalling exclusively through the CCR3 receptor. Eotaxin is upregulated in the lungs within 3h of antigen challenge, levels peak at 6h in lun...