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Diminished IL-10 production in subjects with allergy after infection with influenza A virus

, : Diminished IL-10 production in subjects with allergy after infection with influenza A virus. Journal of Allergy & Clinical Immunology 103(6): 1045-1048, June

Background: Recent studies have documented a link between respiratory viral infections and the expression of asthma and other allergic disorders. Results from other studies have suggested that diminished production of IL-10, an anti-inflammatory cytokine, may contribute to the pathophysiologic features of these diseases. Objective: The objective of this study was to determine whether diminished IL-10 production and TH2 cytokine skewing occur in allergic, as compared with nonallergic, subjects after experimental infection with the influenza A virus. Methods: PBMCs were isolated from 11 subjects with allergy and 14 subjects with no allergy before and after influenza A infection and stimulated with either mitogen (PHA) or antigen (influenza A). Supernatants were assayed for IL-10, IL-4, and IFN-gamma by ELISA. Results: PBMC IL-10 production was significantly diminished in subjects with allergy, as compared with subjects with no allergy, after experimental infection with influenza A virus.However, significant TH2 skewing and enhanced airway symptoms were not observed in these same subjects. Conclusions: These data provide further support that subjects with allergy have an intrinsic inability to upregulate IL-10 production in response to inflammatory stimuli and extend this observation to include respiratory viral infections. Future studies in this area could lead to a better understanding of the pathogenesis of asthma and other allergic disorders.


PMID: 10359884

DOI: 10.1016/s0091-6749(99)70177-6

Other references

Macar Paul, 1937: Sur des cailloux impressionnes de quartzite trouves dans le poudingue burnotien, a Weris. A study of pebble impressions in cobbles and small quartzite boulders found in the Burnotian conglomerate (Devonian) near Weris, Luxembourg, Belgium, shows that these are more probably due to solution than to mechanical pressure.

Wahab, M.A.; Gopalakrishnan, P.K., 1993: Genetic divergence in bittergourd (Momordica charantia L.). Some 50 diverse M. charantia genotypes were grouped into 5 clusters on the basis of D2 analysis of data on 18 vegetative, productive and quality characters. Genetic diversity was not significantly correlated with geographic diversity. Intracluster...

Nordin, N.; Fadaeinasab, M.; Mohan, S.; Mohd Hashim, N.; Othman, R.; Karimian, H.; Iman, V.; Ramli, N.; Mohd Ali, H.; Abdul Majid, N., 2016: Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway. Drug resistance presents a challenge in chemotherapy and has attracted research interest worldwide and particular attention has been given to natural compounds to overcome this difficulty. Pulchrin A, a new compound isolated from natural products...

Shi, A.; Chen, P.; Li, D.X.; Zheng, C.; Hou, A.; Zhang, B., 2008: Genetic confirmation of 2 independent genes for resistance to soybean mosaic virus in J05 soybean using SSR markers. J05 soybean was previously identified to carry 2 independent genes, <i>Rsv1</i> and <i>Rsv3</i>, for "soybean mosaic virus" (SMV) resistance by inheritance and allelism studies. The objective of this research was...

Puntis, J.W.; Booth, I.W.; Buick, R., 1986: Cisapride in neonatal short gut. Lancet 2(8498): 108-109

Singh, S.K.; Kim, S.J., 2013: Does expanded criteria donor status modify the outcomes of kidney transplantation from donors after cardiac death?. The outcomes of kidney transplants that simultaneously exhibit donation after cardiac death (DCD) and expanded criteria donor (ECD) characteristics have not been well studied. We examined the outcomes of DCD versus non-DCD kidney transplants as a...

Anonymous., 1986: Judy Rowe 1938-1985. Mammal Review, 161: 43-45

Bix, H.H.; Marriott, H.J., 1959: Zones of potential interference, dissociation, and fusion: with observations on the contour of retrograde P waves. American Heart Journal 57(3): 423-429

Holter J.B.; Colovos N.F.; Heald C.W., 1969: Heat increments of steam volatile fatty acids infused separately and in a mixture into fasting cows preliminary report. Journal of Dairy Science 52(2): 280-281

Khasawneh, F.E.; Doll, E.C., 1978: The use of phosphate rock for direct application to soils. The topics considered are: the mineralogy and chemistry of phosphate rock; the reactions of phosphate rocks in soil; the agronomic evaluation of phosphate rock for direct application.