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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

, : Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection. Bioorganic & Medicinal Chemistry Letters 11(24): 3099-3102, 17 December

A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.


PMID: 11720851

DOI: 10.1016/s0960-894x(01)00654-0

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