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Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17beta-estradiol and dehydroepiandrosterone sulfate

, : Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17beta-estradiol and dehydroepiandrosterone sulfate. Journal of Clinical Endocrinology and Metabolism 84(3): 975-984

The regulation of androgen synthesis during puberty in females is complicated, with changes in steroidogenic and peripheral interconversion capacity. In the present study we have investigated the diurnal rhythm of testosterone secretion in 56 healthy girls before and during puberty, up to 2 yr postmenarche. The girls' ages ranged between 4.6-16.5 yr, and their height SD scores ranged between -3.6 and +3.7. One to 5 serum profiles (seven samples per 24 h) were taken from each girl for steroid measurements, and a total of 84 serum profiles were obtained. Serum testosterone concentrations were determined using a RIA with a detection limit of 30 pmol/L. The results demonstrate that there is a diurnal rhythm of testosterone secretion during both prepuberty and puberty in girls. The pattern has its nadir in the late evening or just after midnight, with the highest levels in the morning (0600-1000 h). Serum testosterone concentrations in prepubertal girls were significantly lower than those in pubertal girls and were significantly lower in early puberty than in girls in mid- or late puberty. No differences were found in levels between girls in midpuberty or late puberty. Before puberty, serum testosterone concentrations correlated with serum dehydroepiandrosterone sulfate, consistent with the adrenals being the major source of testosterone. After the onset of puberty, a correlation between testosterone and 17beta-estradiol was seen, consistent with the ovaries being the major source of testosterone during puberty. Furthermore, the present study showed that there is a relative hyperandrogenicity in early puberty, with high levels of androgens relative to estrogens.


PMID: 10084582

DOI: 10.1210/jcem.84.3.5524

Other references

Shatalkin, A.I., 1994: Typological approach in systematics. The taxonomic type is considered in the following meanings: 1) type as a specimen for comparison; 2) gestalt quality as an instrument of form perception; 3) archetype sensu Owen; 4) monothetic and polythetic types; synthetic type sensu Sokal; 5) t...

Turpeinen, E., 1944: A study of the blood ether values in man during anesthesia combined with morphine-scopolamine A pharmacological-clinical study. The stages of anesthesia were estimated according to the Guedel scale. The analytic method used was a procedure developed by the author by modification of Widmark's blood alc. micromethod. The total reduction value was regarded as due only to...

Cohen, S.Y., 1998: Acquired prepapillary arterial loop after central retinal artery obstruction. Archives of Ophthalmology 116(10): 1398-1399

Papastamatis S.C., 1970: Renal transplantation pre operative and post operative care. International Surgery 54(3): 183-185

Balls, W.L.wrence; Hancock, H.A., 1926: Measurements of the reversing spiral in cot-ton hairs. The paper embodies selections from a mass of statistical data describing the dimensions and form of the spiral arrangements which occur in the cell wall of cotton hairs. The spirals may be dexter or sinister, and their reversals are apparently pre...

Wu, Q.; Li, Y.; Li, Y.; Gao, S.; Wang, M.; Zhang, T.; Chen, J., 2014: Identification of a novel fungus, Leptosphaerulina chartarum SJTU59 and characterization of its xylanolytic enzymes. Xylanolytic enzymes are widely used in processing industries, e.g., pulp and paper, food, livestock feeds, and textile. Furthermore, certain xylanotic enzymes have demonstrated the capability to improve the resistance and immunity of plants. Scree...

Krishna Ayyar, P.N., 1940: Investigations on Spathius critolaus Nixon, an important Braconid parasite of the cotton-atom weevil, Pempheres affinis Fst. of South India. Indian Journal of Agricultural Science, 10: 879-900

Bauer, J.C.; Young, C.M., 2000: Epidermal lesions and mortality caused by vibriosis in deep-sea Bahamian echinoids: a laboratory study. When significant mortality of the bathyal spatangoid echinoid Paleopneustes cristatus occurred under laboratory conditions, we investigated the cause and course of the disease by culturing and identifying internal pathogens, then experimentally in...

Botkin, DB., 1980: A grandfather clock down the staircase stability and disturbance in natural ecosystems. PROCEEDINGS OF THE ANNUAL BIOLOGY COLLOQUIUM (OREGON STATE UNIVERSITY): 1-10 No. 40

Seeliger, H.P., 1977: Cryptococcosis: a diagnostic challenge. The importance of early diagnosis for clinical outcome is stressed and reliable and rapid tests are outlined and pitfalls discussed with reference to 25 cases of human Cryptococcus neoformans infection. Direct microscopy is essential, followed by...