+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dopamine pretreatment in mice diminishes the hematotoxic effects of cyclophosphamide

, : Dopamine pretreatment in mice diminishes the hematotoxic effects of cyclophosphamide. Biogenic Amines 15(5): 465-475

An investigation was carried out to examine whether dopamine (DA) has any protective effect on anticancer drug-induced hematotoxicity. Normal Swiss mice were injected i.p. with 50 mg / kg body weight / day of DA for five consecutive days. After 24 hr of last DA injection, cyclophosphamide (CY) was injected i.v. at a single dose of 200 mg / kg body wt. CY injection was followed by marked inhibition of total circulating leukocyte count, severe neutropenia, bone marrow and splenic hypocellularity and profound diminution of granulocytic and erythroid cells in the bone marrow. DA treatment prior to CY injection elicited appreciable protection against these adverse effects of CY. For instance, leukopenia and neutropenia were of lesser magnitude and the nadir were observed on day 4 instead of day 2 in CY-only group. In addition, total WBC and neutrophil recovery were completed by day 6 after CY injection which was 72 hr earlier than the group which did not receive DA before CY. Cytological and cytochemical studies revealed reduction in the severity of suppressive effect of CY on bone marrow granulocytes and their progenitors in mice pretreated with DA. Substantial increments in the number of megakaryocytes and erythroid cells were observed in the spleen of DA - treated animals. Thus, it is concluded that DA treatment before CY mediates appreciable reduction in the severity of hematotoxicity elicited by this cancer chemotherapeutic agent.


Other references

Piyathilake, C.J.; Badiga, S.; Kabagambe, E.K.; Azuero, A.; Alvarez, R.D.; Johanning, G.L.; Partridge, E.E., 2012: A dietary pattern associated with LINE-1 methylation alters the risk of developing cervical intraepithelial neoplasia. There is a paucity of research examining the relationships between dietary patterns and risk of developing precancerous lesions as well as biomarkers associated with such dietary patterns. The purpose of the current study was to identify dietary p...

Melzer H., 1967: Helictotrichon petzense m new species a newly discovered endemic from the southeastern calciferous alps. Oesterreichische Botanische Zeitschrift 114(3): 307-319

Sameshima, S.; Hasegawa, E.; Kitade, O.; Minaka, N.; Matsumoto, T., 1999: Phylogenetic comparison of endosymbionts with their host ants based on molecular evidence. The nucleotide sequences of 16S ribosomal RNA (rRNA) of endosymbionts and mitochondrial cytochrome oxidase subunit I (COI) of their host were determined in five genera of the subfamily Formicinae (Camponotus, Colobopsis, Formica, Plagiolepsis and...

Romanov, G.A.; Taran, V.Y.; Orudzhev, E.M., 1992: Zeatin-binding proteins of cereals: age, organ, tissue and subcellular aspects. Zeatin-binding proteins (ZBP) with similar properties were found in vegetative organs of barley, maize and wheat. ZBP in barley were detected in green first-storey leaves of different ages (from 3 to 18 d), as well as in second-storey leaves and i...

George, D.T.; Bitler, D.A.; Linnoila, M., 1994: Reaction to sodium lactate infusion in perpetrators of domestic violence. Biological Psychiatry 35(9): 737

Dalmark, M.; Wieth, J.O., 1970: Chloride and sodium permeabilities of human red cells. Biochimica et Biophysica Acta 219(2): 525-527

Boyd, M.R.; Dutcher, J.S., 1981: Renal toxicity due to reactive metabolites formed in situ in the kidney: investigations with 4-ipomeanol in the mouse. The in vitro metabolism and covalent binding of the furan derivative, 4-ipomeanol, was mediated by oxygen-requiring, NADPH-dependent, CO-inhibitable microsomal enzymes present in the livers, lungs and kidneys of adult male mice. These activities w...

Hohjyo, K., 1979: Study of the non-acoustic stapedius reflex elicited by electrocutaneous stimulation. Nihon Jibiinkoka Gakkai Kaiho 82(7): 689-701

Jairath, V.; Levesque, B.G.; Vande Casteele, N.; Khanna, R.; Mosli, M.; Hindryckx, P.; Travis, S.; Duijvenstein, M.; Rimola, J.; Panes, J.; D'Haens, G.; Sandborn, W.J.; Feagan, B.G., 2016: Evolving Concepts in Phases I and II Drug Development for Crohn's Disease. NlmCategory="UNASSIGNED">The highest attrition rates during drug development programmes occur at the proof of concept stage. Given the large number of molecules under development for Crohn's disease, a need exists to improve the...

Baxter, John L., 1961: Results of the 1955 to 1959 Pismo clam censuses. Censuses showed a decline in numbers of harvestable Pismo clams (Tivela stultorum) at both Pismo Beach and Morro Bay. There was good spawning survival at Pismo Beach in 1957, 1958 and 1959 but virtually no recruitment at Morro Bay. It is demonstra...