geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ectopic HP1 promotes chromosome loops and variegated silencing in Drosophila


, : Ectopic HP1 promotes chromosome loops and variegated silencing in Drosophila. Embo Journal 20(4): 812-818

A transgene inserted in euchromatin exhibits mosaic expression when targeted by a fusion protein made of the DNA-binding domain of GAL4 and the heterochromatin-associated protein HP1. The silencing responds to the loss of a dose of the dominant modifiers of position-effect variegation Su(var)3-7 and Su(var)2-5, the locus encoding HP1. The genomic environs of the insertion site at 87C1 comprise the dispersed repetitive elements micropia and alphagamma. In the presence of the GAL4-HP1 chimera, the polytene chromosomes of this line form loops between the insertion site of the transgene and six other sections of chromosome 3R, as well as, rarely, with pericentric and telomeric heterochromatin. In contrast to the insertion site of the transgene at 87C, the six loop-forming sites in the euchromatic arm were each previously described as intercalary heterochromatin. Moreover, GAL4-HP1 tethering on one homologue trans-inactivates the reporter on the other. HP1, probably together with other partners, could thus facilitate the coalescence of dispersed middle repetitive sequences, and organize the heterochromatic structure responsible for the variegated silencing of nearby euchromatic genes.

US$19.90

PMID: 11179225

DOI: 10.1093/emboj/20.4.812


Other references

Weißflog, G.; Spangenberg, L., 2016: Ambulatory Assessment in Clinical and Psychological Research. Psychotherapie, Psychosomatik, Medizinische Psychologie 66(2): 93-94

Mailleux, P.; Fontaine, D.; Mairesse, M.; Coulier, B.; Coppens, J.P.; Joris, J.P., 1990: Endobronchial lipoma: a potential CT diagnosis. Bronchial lipomas are rare and benign neoplasms. Computed tomography can provide a powerful adjunct to conventional modalities in determining the nature of an endobronchial lesion. The reflex vasoconstriction can also be nicely depicted.

Udupa, K.N.; Singh, R.H., 1966: Isotopic studies on the effect of certain anabolic and anllanabolic hormones on the turnover of minerals and mucopolysaccharides in healing of fractures. The pattern of the uptake of S35 and Ca45 in fractured bones during repair has been studied in animals treated with methandrostenolone and cortisone acetate. It has been observed that methandrostenolone causes exaggerated mucopolysaccharide respon...

Tumanyan, S.S.; Tumanyan, S.V.; Rymashevski, A.N., 2015: Predictors of renal dysfunction and its correction in women with preeclampsia and alimentary obesity. Alimentary obesity (AO) is considered as an independent risk factor for preeclampsia (PE). Diagnosis of renal dysfunction in the development of PE is difficult. Early detection of renal dysfunction in women with PE and AO and substantiation of pri...

Malyshev, S.I., 1956: Processes and conditions in the evolution of instincts in Hymenoptera vespiformia s. lat. Trudy Vsesoyuznogo Entomologicheskogo Obshchestva Leningrad, 45: 3-50

Caprioli, D.; Venniro, M.; Zeric, T.; Li, X.; Adhikary, S.; Madangopal, R.; Marchant, N.J.; Lucantonio, F.; Schoenbaum, G.; Bossert, J.M.; Shaham, Y., 2016: Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model. Cue-induced methamphetamine craving increases after prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine craving). Here, we determined whether this incubation phenomenon would occur under conditions that...

Krasnikov, A.A., 1991: Chromosome numbers in Achyrophorus maculatus from Siberia and Kazakhstan. Botanicheskii Zhurnal (St Petersburg) 76(4): 625

Catchpole, N., 1946: Simple pruning. In the first two chapters of this small book, on the purpose and form of pruning, the author gives practical examples of diverse plants to support the theoretical work he is describing, while adequate illustration by plates and line drawings simpl...

Smart J.S., 1972: Quantitative Characterization of Channel Network Structure. Eos, Transactions, American Geophysical Union: , Pages 370. 1972.

Shvartsburg, A.A.; Clemmer, D.E.; Smith, R.D., 2011: Isotopic effect on ion mobility and separation of isotopomers by high-field ion mobility spectrometry. Distinguishing and separating isotopic molecular variants is important across many scientific fields. However, discerning such variants, especially those producing no net mass difference, has been challenging. For example, single-stage mass spectr...