geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ectopic breast tissue as a possible cause of false-positive axillary sentinel lymph node biopsies


, : Ectopic breast tissue as a possible cause of false-positive axillary sentinel lymph node biopsies. American Journal of Surgical Pathology 27(4): 513-518

Epithelial inclusions representing ectopic breast tissue are uncommonly seen in axillary lymph nodes. The extensive histopathologic examination of axillary sentinel lymph nodes of patients with breast carcinoma may increase the chances to encounter tiny foci of ectopic breast tissue, which may be misinterpreted as (micro)metastatic disease and lead to unwarranted completion of axillary dissection and to inaccurate staging and improper adjuvant treatments for the patients. Here we report on seven cases of ectopic breast tissue in axillary sentinel lymph nodes. In three cases there were coexistent micrometastases, and in the remaining cases the ectopic tissue was not associated with metastatic disease. The ectopic breast tissue showed remarkably varied morphologic features, including apocrine metaplasia and proliferative changes indistinguishable from those occurring in sclerosing adenosis and florid epithelial hyperplasia of the breast. A peripheral layer of myoepithelial cells was consistently detected in the ectopic glands and ducts. Besides awareness and purely morphologic criteria, a false-positive identification of these inclusions as metastatic carcinoma may be avoided by the use of immunohistochemical reactions for the localization of specific markers of the myoepithelial cell component, which is associated with the ectopic breast tissue.

US$19.90

PMID: 12657937

DOI: 10.1097/00000478-200304000-00012


Other references

Lidén, S., 1985: Grenz ray treatment--time for reappraisal?. Photo-Dermatology 2(6): 337-338

Spitzer, K.W.; Sato, N.; Tanaka, H.; Firek, L.; Zaniboni, M.; Giles, W.R., 1997: Electrotonic modulation of electrical activity in rabbit atrioventricular node myocytes. Electrotonic effects of electrically coupling atrioventricular (AV) nodal cells to each other and to real and passive models of atrial and ventricular cells were studied using a technique that does not require functional gap junctions. Membrane po...

Sherck, N.J.; Won, Y-Yeon., 2017: Technical Note: A simulation study on the feasibility of radiotherapy dose enhancement with calcium tungstate and hafnium oxide nano- and microparticles. To assess the radiotherapy dose enhancement (RDE) potential of calcium tungstate (CaWO<sub>4</sub> ) and hafnium oxide (HfO<sub>2</sub> ) nano- and microparticles (NPs). A Monte Carlo simulation study was conducted to gauge...

Wiest, L.; Chonova, T.; Bergé, A.; Baudot, R.; Bessueille-Barbier, Fédérique.; Ayouni-Derouiche, L.; Vulliet, E., 2017: Two-year survey of specific hospital wastewater treatment and its impact on pharmaceutical discharges. It is well known that pharmaceuticals are not completely removed by conventional activated sludge wastewater treatment plants. Hospital effluents are of major concern, as they present high concentrations of pharmaceutically active compounds. Despi...

Nazarenko, Oa, 1980: Improvement of the work of the photosynthetic apparatus of winter wheat plants by presowing treatment of the seeds with chlorocholine chloride (CCC). Povyshenie produktivnosti ozimoi pshenitsy: 54-160

Stewart Oaten, A.; Murdoch, W.W.; Walde, S.J., 1995: Estimation of temporal variability in populations. A common measure of the temporal variability of a population is the standard deviation of the logarithms of successive estimated population sizes, ln(D-t). This measure overestimates true temporal variability (the standard deviation of the logarit...

Laterra, J.; Indurti, R.R.; Goldstein, G.W., 1993: Plasminogen activation and astroglial-induced neural microvessel morphogenesis. Advances in Experimental Medicine and Biology 331: 189-199

Visser, O.; van den Berg, J.W.; Koole-Lesuis, H.; Voortman, G.; Wilson, J.H., 1991: Porphyrin synthesis by human hepatocytes and HepG2 cells--effects of enzyme inducers and delta-aminolevulinic acid. Experiments were carried out to investigate the possibility of inducing porphyria in human hepatocytes and HepG2 cells in culture. After treatment with hexachlorobenzene, 3-methylcholanthrene, phenobarbital or dimethyl sulfoxide, protoporphyrin wa...

Anderson, R.C.; Anderson, J.H., 2003: Sensory irritation testing. Journal of Occupational and Environmental Medicine 45(5): 467-8; Author Reply 468

Idris, I.; Al-Ubaidi, F., 2010: Discordance between non-HDL cholesterol and LDL cholesterol levels in patients with diabetes without previous cardiovascular events. Despite achieving desirable LDL cholesterol levels, the residual cardiovascular (CV) risk remains high among patients with diabetes. This is partly due to the increased number of atherogenic LDL particles and apoB levels, despite optimal LDL level...