+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach

, : Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach. Cancer Epidemiology, Biomarkers & Prevention 11(8): 739-744

Guanylyl cyclase C (GC-C), a receptor specifically expressed in cells originating from differentiated intestinal epithelium, is a marker and therapeutic target for colorectal cancer metastases. Intestinal metaplasia, in which epithelial cells assume histological and molecular characteristics of differentiated intestinal enterocytes, is a common precursor to adenocarcinomas of the esophagus and stomach. Thus, those tumors, tissues adjacent to them, and their associated regional lymph nodes were assessed for GC-C expression by reverse transcription coupled with the PCR. GC-C mRNA was detected in five of five and eight of nine esophageal and gastric adenocarcinomas, respectively. Also, GC-C mRNA was detected in three of five and six of seven tissues adjacent to, but not histologically involved in, esophageal and gastric adenocarcinomas, respectively, reflecting molecular changes associated with neoplastic transformation preceding histopathological changes. In contrast, three normal gastric specimens did not express GC-C. Furthermore, GC-C mRNA was detected in 1 of 1 lymph node containing tumor cells by histopathology from a patient with gastric adenocarcinoma and in 3 of 11 lymph nodes, all of which were free of tumor cells by histopathology, from a patient with a gastroesophageal junction tumor. This is the first demonstration that GC-C is ectopically expressed by primary and metastatic adenocarcinomas of the esophagus and stomach and suggests that GC-C may be a sensitive and specific clinical marker and target for adenocarcinomas of the upper gastrointestinal tract.


PMID: 12163327

Other references

Beaudry, M.; Galibois, I.; Chaumette, P., 1996: Does consumption of milk products achieve nutritional recommendations?. The hypothesis that people who consume recommended amounts of milk products also better meet new Canadian nutrition recommendations was examined using data from the Quebec nutrition survey carried out under the Canadian Heart Health Initiative in...

Lizal, F.; Opletalova, L., 1965: Effect of urea, dicyandiamide and crude biuret in the ration on weight gain, N retention and digestibility of organic nutrients by bulls. For 100 days from initial liveweights of from 168 to 263 kg 6 Czechoslovak Red Spotted bulls were given about 75% of Morrison's standard (see Title 6058, Vol. 27) for protein with the full amount of energy. The ration was of grass hay 2.1, ma...

Schrenk W.J.; Miller J.H., 1974: Specialized transducing phages carrying fusions of the trp and lac regions of the escherichia coli chromosome. Molecular & General Genetics 131(1): 9-19

Clochard, M.; Mattmann, E.; Mercier, Fçois.; Ricard, L.; Mathey, Fçois., 2003: Phosphinites derived from the 7-phosphanorbornene skeleton: first results in asymmetric catalysis. [structure: see text] The bisphosphinite 4 incorporating two 7-phosphanorbornene subunits is an efficient ligand for the Rh-catalyzed enantioselective hydrogenation of functional alkenes in terms of rate and enantioselectivity. This type of struct...

Roth E.; Lucas M.; Lecomte T.; Devillers C.; Hagemann R., 1975: Geochemical assessment of the extent and frequency of Oklo-type phenomena. Pages 489-498:

Crowe P.; Gertzbein S.D., 1990: Spinal canal clearance in burst fractures using the ao internal fixator. Orthopaedic Transactions 14(3): 777-778

Sakaue, H.; Kiryu, J.; Takeuchi, A.; Yamamoto, F.; Honda, Y., 1992: Effects of endothelin on retinal blood vessels. Endothelins (ETs), which are one of the most potent vasoconstrictors, were discovered in 1988. ETs are involved in the regulation of vascular smooth muscle and are thought to function like a local hormone. In this study, we measured changes in the...

Mandigo, Theodore, 1984: Blind faith, lax controls offer potential for cash theft. Setting up basic rules for handling cash protects both the restaurant and the employees. While robbery may be a very costly experience, in-house employee theft is much more common and potentially more devestating. Petty cash theivery can occur at...

Herbert, J.M.; Hérault, J.P.; Bernat, A.; Savi, P.; Schaeffer, P.; Driguez, P.A.; Duchaussoy, P.; Petitou, M., 2001: SR123781A, a synthetic heparin mimetic. SR123781A, a synthetic hexadecasaccharide comprising an antithrombin (AT) binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained from glucose through a convergent synthesis. SR123781A showed high...

Rao, C.K.; Mittal, B.N.; Dharmshaktu, N.S., 1988: Leprosy control based on multidrug treatment in India. The authors describe progress in the implementation of multiple-drug therapy in the National Leprosy Eradication (formerly Control) Programme in India. The Programme started in 1955 and was revised in 1976 with new targets for case detection and t...