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Ectopic lymphoid organogenesis: a fast track for autoimmunity

, : Ectopic lymphoid organogenesis: a fast track for autoimmunity. American Journal of Pathology 159(3): 787-793

Medical records are generally accepted as the most accurate source of information documenting cancer treatments. However, as the health care system becomes more decentralized and more cancer care is delivered in outpatient settings, it is increasingly difficult and expensive to review records from the many surgeons and medical/radiation oncologists who administer cancer therapies in the community setting. Using 1994-1995 data, the authors compared initial treatment for prostate cancer self-reported (from a mailed questionnaire or telephone/in-person interview) by 3,196 US men in the population-based Prostate Cancer Outcomes Study with information obtained from medical records. Agreement between self-reports and medical records varied by type of treatment. Generally, agreement was excellent for more invasive procedures such as prostatectomy or radiation (kappa values > 0.8), with decreasing agreement for hormone shots and pills (kappa values < 0.7). If the medical record abstract is assumed to be the "gold standard," the estimated sensitivity was generally high (>80%) for prostatectomy and radiation but low (68%) for hormone pills, although the estimated specificity was 90% or greater for all treatments. These results can serve as a useful guide to researchers contemplating the use of surveys as an alternative to medical record abstraction to ascertain treatment in studies of patient outcomes.


PMID: 11549568

DOI: 10.1016/S0002-9440(10)61751-8

Other references

Semino, O.; Magri, C.; Benuzzi, G.; Lin, A.A.; Al-Zahery, N.; Battaglia, V.; Maccioni, L.; Triantaphyllidis, C.; Shen, P.; Oefner, P.J.; Zhivotovsky, L.A.; King, R.; Torroni, A.; Cavalli-Sforza, L.Luca.; Underhill, P.A.; Santachiara-Benerecetti, A.Silvana., 2004: Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area. The phylogeography of Y-chromosome haplogroups E (Hg E) and J (Hg J) was investigated in >2,400 subjects from 29 populations, mainly from Europe and the Mediterranean area but also from Africa and Asia. The observed 501 Hg E and 445 Hg J sample...

Palomino G.; J.A., 1953: Bromatological study of Sciaena starksi (a shore fish). The flesh of the shore fish " robalo " (Sciaena starksi) contained, per cent. on fresh basis, protein 18.84, fat 2.82, carbohydrate 0.05 and ash 0.92. There was a high tyrosine content, 0.69 per cent., and a low tryptophan content, 0.20...

Ketel, A.P., 1953: Data on occurrence of pulmonary tuberculosis in the Rotterdam municipal psychiatric hospital Maasord in Portugal. Geneeskundige Bladen Uit Kliniek en Laboratorium Voor de Praktijk 45(12): 367-410

Abe T., 1967: Records from northern japan of 2 females of ceratias holboelli each parasitized by a male. Proceedings of the Japan Academy 43(8): 797-800

Asch, D.A.; Nicholson, S.; Srinivas, S.; Herrin, J.; Epstein, A.J., 2009: Evaluating obstetrical residency programs using patient outcomes. Patient outcomes have been used to assess the performance of hospitals and physicians; in contrast, residency programs have been compared based on nonclinical measures. To assess whether obstetrics and gynecology residency programs can be evaluate...

Bacher, A.; Andel, H.; Grabner, V.; Twrdy, T.; Zadrobilek, E.; Lackner, F., 1994: Is laparoscopic cholecystectomy the appropriate technique for cardiopulmonary high-risk patients?. Wiener Klinische Wochenschrift 106(4): 97-102

Guéant-Rodriguez, R-M.; Juillière, Y.; Nippert, M.; Abdelmouttaleb, I.; Herbeth, B.; Aliot, E.; Danchin, N.; Guéant, J-L., 2007: Left ventricular systolic dysfunction is an independent predictor of homocysteine in angiographically documented patients with or without coronary artery lesions. Elevated plasma homocysteine is a risk factor for coronary artery disease (CAD) and thromboembolic disorders that seems also to be associated with chronic heart failure. To evaluate the association between homocysteine and left ventricular dysfunc...

Sansome, E.R.; Demerec, M.; Hollaender, A., 1945: Quantitative irradiation experiments with Neurospora crassa. I. Experiments with X-rays. Microconidia were irradiated with X-rays. The increase in mutation rate with increase in energy followed a straight-line relationship at low dosages and reached 78.5% at 126,000 roentgens. Increase in intensity led to an increase in the mutation r...

Wojcik, P.; Czaja, H., 2001: Przyczyny brakowania krow w gospodarstwach rolnych na terenie Polski Poludniowej. The purpose of this study was to analyse reasons for culling cows in south Poland in a group of primiparous cows calved in 1997 and to show the relationship between reasons for culling and milk yield, age at first conception and calving. Data on m...

Gharkheloo, M.Mouradi, 2006: Morphological and karyological peculiarities of Cricetulus migratorius (Pallas, 1773) (Mammalia: Rodentia) in the Zanjan province of Iran. The diploid number of chromosomes of Cricentulus migratorius in Zanjan, Iran, was 2n = 22, the fundamental number of chromosomes NF = 42 and the numbers of chromosomal arms Nfa = 38. Based on the positions of the centromere, the autosomes were div...