geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Edatrexate (10-ethyl-deaza-aminopterin) (NSC 626715) with or without leucovorin rescue for malignant mesothelioma: Sequential Phase II trials by the Cancer and Leukemia Group B


, : Edatrexate (10-ethyl-deaza-aminopterin) (NSC 626715) with or without leucovorin rescue for malignant mesothelioma: Sequential Phase II trials by the Cancer and Leukemia Group B. Cancer 86(10): 1985-1991

BACKGROUND: The Cancer and Leukemia Group B (CALGB) conducted sequential Phase II multicenter trials to evaluate the activity of edatrexate alone (E) or with leucovorin rescue (EL) in patients with malignant pleural mesothelioma. (CALGB Protocol 9131). METHODS: Twenty patients were accrued to the E portion of the study and received edatrexate, 80 mg/m2, intravenously over 20-30 minutes weekly. After a protocol amendment precipitated by excessive toxic events with E, 40 patients were enrolled in the EL arm and received the same dose of edatrexate with leucovorin, 15 mg orally, every 6 hours for 4 doses beginning 24 hours after edatrexate. Eligibility criteria included a CALGB performance status of 0-2 and no prior chemotherapy. A central pathology review was performed. Of the 58 patients included in this analysis (20 receiving E and 38 receiving EL), 36 had epithelial cell type and 22 had mixed or sarcomatous cell types. There were 31 patients with measurable disease and 27 with evaluable disease. RESULTS: The overall response rate was 25% for E (95% confidence interval (95% CI), 9-49%) and 16% for EL (95% CI, 6-31%). There was a 5% complete response (CR) rate, a 10% partial response (PR) rate, and a 10% regression (R) rate for E and a 0% CR rate, a 3% PR rate, and a 13% R rate for EL. The median survival duration from study entry was 9.6 months and 6.6 months, respectively, for E and EL; 1-year survival was 50% and 32%, respectively, for E and EL. There were four early deaths with the E regimen (including two from neutropenic sepsis) and one early death with the EL regimen (from progressive disease). Principal toxicities included mucositis, myelosuppression, and rash, which were less frequent with leucovorin rescue. CONCLUSIONS: Moderate antitumor activity has been observed with both regimens. Leucovorin rescue ameliorated the mucosal, hematologic, and dermatologic toxicities of edatrexate, but also may have reduced its efficacy.

US$19.90

PMID: 10570422

DOI: 10.1002/(sici)1097-0142(19991115)86:10<1985::aid-cncr15>3.0.co;2-h


Other references

Anonymous, 1997: Medicare reimbursement for NPs and CNSs to be a reality, January 1, 1998. South Carolina Nurse 4(4): 32-33

Moravec, J.; Kvasnicka, S.; Jelinek, J., 1973: Breeding the shallot variety Milka (Allium cepa var. ascalonicum (L) Backer 1951). Selected from a regional variety, Milka has symmetrical bulbs weighing 25-40 g mostly 3-4 cm in diameter, and 6-9 bulbs per plant. The growing period for green shallots is 50-70 days and for dry bulbs 80-130 days from a spring planting. Milka give...

Anderson, W.S.; Kiyofuji, S.; Conway, J.E.; Busch, C.; North, R.B.; Garonzik, I.M., 2009: Dysphagia and neuropathic facial pain treated with motor cortex stimulation: case report. We report on a patient with a neuropathic facial pain syndrome, including elements of trigeminal neuralgia, glossopharyngeal neuralgia, and dysphagia. After failing medical and surgical decompressive treatments, the patient underwent implantation...

Renna V.; Leaci R., 1980: Timolol maleate in ophthalmic surgery. The ability of timolol maleate to reduce intraocular pressure in uncomplicated intracapsular cataract extraction was evaluated. The efficacy during 40 operations was excellent.

Torras Casals, C., 1996: Species of Alloxystinae Hymenoptera, Cynipoidea, Charipinae, hyperparasites of aphids in Barcelona province Especies de Alloxystinae Hymenoptera, Cynipoidea, Charipinae, hiperparasitos de afidos en la provincia de Barcelona. Unknown

MacNeill, C.C.; Carey, J.C., 2001: Recurrent vulvovaginal candidiasis. Widespread use of over-the-counter antifungal medications has contributed to a large increase in the number of women who experience more than three episodes of candida vulvovaginitis per year. These women are particularly prone to chronic vulvovag...

Davidson Charles F., 1955: Concentration of uranium by carbon compounds. Reaffirms the conclusion that formation of thucholite is due to polymerization of hydrocarbonsby radioactive minerals.

Sharma, H.R.; Chauhan, G.S., 2000: Physical, sensory and chemical characteristics of wheat breads supplemented with fenugreek (Trigonella foenum graecum L.). Addition of fenugreek (Trigonella foenum graecum L.) to wheat flour up to the 3% level increased the baking absorption of wheat flour without exhibiting a loaf volume depression effect and addition up to the 7.5% level gave a satisfactory loaf vol...

Mail, N.; Moseley, D.J.; Siewerdsen, J.H.; Jaffray, D.A., 2009: An empirical method for lag correction in cone-beam CT. Image lag degrades image quality in cone-beam CT (CBCT), resulting in contrast reduction, lack of CT number accuracy and uniformity, and skin-line artifacts. The magnitude of such degradation and the extent to which imaging performance can be impr...

Cook, D.J.; Sackett, D.L.; Spitzer, W.O., 1995: Methodologic guidelines for systematic reviews of randomized control trials in health care from the Potsdam Consultation on Meta-Analysis. Journal of Clinical Epidemiology 48(1): 167-171