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Editorial: Optimale Thrombolyse

, : Editorial: Optimale Thrombolyse. Zeitschrift fuer Kardiologie 90(8): 591-595

Thrombolytic therapy is an established reperfusion strategy in acute myocardial infarction with proven long-term survival benefit. New thrombolytic agents including reteplase, lanoteplase, and tenecteplase have been developed to optimize thrombolytic therapy. With respect to efficacy the new thrombolytic agents show mortality equivalent to front-loaded alteplase, the present gold standard of thrombolytic therapy. With respect to ease of application there are advantages because third generation agents can be given as a single or double bolus instead of a bolus followed by an infusion. The most promising strategy to optimize coronary thrombolysis seems to be the combination of thrombolytic agents in reduced dose and GP IIb/IIIa blockers in full dose. The corresponding clinical trials (TIMI-14, SPEED, and INTRO-AMI) have also shown that there is an evolution in the surrogate end points for an optimal thrombolysis. In the past, optimal thrombolysis was associated with an open infarct-related coronary artery. A few years ago it was realized that TIMI-3 flow in the epicardial coronary artery was associated with the best results. Presently, normal myocardial microcirculation is regarded an additional prerequisite for further reduced mortality in acute myocardial infarction.


DOI: 10.1007/s003920170129

Other references

Chudakov, L.I., 1967: An amplifier for intra- and extracellular registration of biopotentials using high-ohmic electrodes. Tsitologiia 9(3): 368-371

Ell, C., 1987: New therapeutic procedures in gallstone disease. Fortschritte der Medizin 105(14): 271-273

Parrott, E.L.; Simpson, M.; Flanagan, D.R., 1983: Dissolution kinetics of a three-component solid II: benzoic acid, salicylic acid, and salicylamide. The dissolution rates of each component in compressed spheres consisting of three components were measured under sink conditions. The observed dissolution rates of benzoic acid, salicylic acid, and salicylamide compare favorably to the predicted d...

Latkovics I.; Varga G., 1968: Role of nitrogen in mineral fertilizer in maize m growth studied with the aid of labelled nitrogen 15. Krippner, Monica (Editor) Isotope Studies on The Nitrogen Chain 343p Illus International Atomic Energy Agency: Vienna, Austria (Dist in The U S By Unipub, Inc : New York, N Y ) 109-117

Lee, J-Young.; Rajesh Kumar, J.; Kim, J-Soo.; Park, H-Kyu.; Yoon, H-Sung., 2009: Liquid-liquid extraction/separation of platinum(IV) and rhodium(III) from acidic chloride solutions using tri-iso-octylamine. Liquid–liquid extraction/separation of platinum(IV) and rhodium(III) from acidic chloride solutions was carried out using tri-iso-octylamine (Alamine 308) as an extractant diluted in kerosene. The percentage extraction of platinum(IV) and rh...

Seldon, B.; Hyde, W., 1991: Welfare gains from wood preservatives research. The economic productivity of publicly funded wood preservatives research from 1950 to 1980 exemplifies public research in the forest product industries. We find a high internal rate of return for wood preservatives, nearly 300 percent. The researc...

Post, S., G.; Whitehouse, P., J., 1995: Fairhill guidelines on ethics of the care of people with Alzheimer's disease: A clinical summary. These guidelines summarize the content of meetings of family caregivers and individuals with dementia of the Alzheimer's type who identified and spoke on ethical issues in dementia care and who engaged in dialogue with an interdisciplinary an...

Agnew, D.; Kennedy, D., 2005: Thirteen years of student leadership conferences: Lessons learned. NACTA journal 49(4): 41-45

Popkov, A.; Blahutova, A.; Kanova, M., 2007: Can 6-fluoroDOPA be an accurate alternative for beta-DOPA?. Journal of Labelled Compounds and Radiopharmaceuticals 50(5-6): 528-529

Saeman, Jf, 1977: Improved use of hardwood resource needed. National hardwood magazine: 51 (6) 56-60