+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Editors and editing of anti-DNA receptors

, : Editors and editing of anti-DNA receptors. Immunity 15(6): 947-957, December

Receptor editing is a means by which immature bone marrow B cells can become self-tolerant. Rearrangements of heavy (H) and/or light (L) chain genes are induced by encounter with autoantigens to change the specificity from self to nonself. We have developed site-directed transgenic mice (sd-tg) whose transgenes code for the H chain of antibodies that bind DNA. B cells that express the transgenic H chain associate mainly with four of the 93 functional Vkappa genes of the mouse. Numerous aspartate residues that might inhibit DNA binding by the VH domain distinguish these L chain Vkappa sequences, but engaging these Vkappa editors often requires multiple rearrangements. Among the edited B cells is a subset of multispecific cells that express multiple receptors. One consequence of multispecificity is partial autoreactivity; these multi-specific B cells may contribute to autoimmunity.


DOI: 10.1016/s1074-7613(01)00251-5

Other references

Tomita T., 1972: The electro retinogram as analyzed by micro electrode studies. Fuortes, M G F (Ed ) Handbook Of Sensory Physiology, Vol Vii 2 Physiology Of Photoreceptor Organs X+765p Illus Springer-Verlag: Berlin, West Germany; New York, N Y , U S A 635-665

Zanardo, V.; Trevisanuto, D.; Cagdas, S.; Grella, P.; Cantarutti, F., 1997: Prenatal theophylline and necrotizing enterocolitis in premature newborn infants. To determine whether prenatal theophylline therapy would increase the incidence of neonatal necrotizing enterocolitis (NEC) we studied bowel dysfunction in 59 consecutive premature infants (g.s. < 34 weeks), whose mothers were treated with theo...

Goth, A., 1945: The antitubercular activity of aspergillic acid and its probable mode of action. Aspergillic acid in low concentrations inhibits the growth of human strains of Myco. tuberculosis. Suggestive evidence is presented which indicates that the mode of action of aspergillic acid can be explained on the basis of interference with the...

Dolinskas C.A.; Bilaniuk L.T.; Zimmerman R.A.; Kuhl D.E., 1977: Computed tomography of intra cerebral hematomas part 1 transmission computed tomography observations on hematoma resolution. AJR (American Journal of Roentgenology) 129(4): 681-688

Dickens, C.H.; Adlers, L., 1972: A study of diameter tape and caliper used in diameter measurements. Reports a study in 1970 on 33 barked Eucalypt logs and 19 unbarked Pine logs. Diameter measurements with a caliper (mean of two readings at right angles) were more accurate than those with a diameter tape. Over-estimates were greater for unbarked...

Prof. Dr. Klaus Altland; Angelika Banzhoff; Rolf Hackler; Ute Rossmann, 1984: Improved rehydration procedure for polyacrylamide gels in presence of urea demonstration of inherited human prealbumin variants by isoelectric focusing in an immobilized ph gradient. Polyacrylamide gels containing immobilized pH gradients (IPGs) are usually extensively washed in deionized water after polymerization and dried when longer storage is required. The original volume of the gel is readjusted by rehydration in water o...

Gaur, R.K.; Singh, A.P.; Singh, A.K.; Maneesha Singh; Raol, G.P.; Mishra, L.C., 2003: Serological identification of sugarcane yellow leaf luteovirus (SCYLV) from cane stalk juice. Sugarcane (Saccharum sp.) hybrids are widely infected with sugarcane yellow leaf virus (SCYLV) causing mid-rib yellowing symptoms. In the present study, direct antigen coating enzyme linked immunosorbant assay (DAC-ELISA) and dot blot immunoassay...

D.M.Rco.F.; Cantarella.R., 1952: Pleurocavitary tuberculosis treated by aspiration; clinical case. Archivio di Tisiologia E Delle Malattie Dell'apparato Respiratorio 7(7): 607-612

Kim, Y-Sook.; Jin, S-Ha., 2004: Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and -3 and up-regulation of Bax in human neuroblastoma. In human neuroblastoma SK-N-BE(2) cells undergoing apoptotic death induced by ginsenoside Rh2, a dammarane glycoside that was isolated from Panax ginseng C. A. Meyer, caspase-1 and caspase-3 were activated. The expression of Bax was increased in t...

Krieger Poullet M., 1972: Various types of nerve endings in the carotid labyrinth of the toad bufo bufo. Journal de Microscopie (Paris) 14(2): 59A