+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Edmund Randerath (1899-1961): experimental proof for the glomerular origin of proteinuria

, : Edmund Randerath (1899-1961): experimental proof for the glomerular origin of proteinuria. Kidney International 56(4): 1591-1596

A century ago, Edmund Randerath (1899-1961), who was one of the pioneers in nephrology that provided indirect experimental proof for the glomerular origin of proteinuria, was born. In the first decades of this century, the concept prevailed that "nephrosis" was a process of primary tubular cell degeneration. In contrast to prevailing opinion, he interpreted these changes to be the result of the uptake and storage of serum proteins after they had been filtered in the glomerulus. Edmund Randerath proved the glomerular origin of proteinuria by astute experiments in amphibia. In the salamander, an intraperitoneal injection of albumin provoked the supposedly "degenerative" changes of tubular epithelial cells in only those nephrons that drained the coelomic cavity and were devoid of glomeruli, but not in those nephrons that were closed and attached to glomeruli. This observation provided incontrovertible evidence that the presence of serum proteins in tubular fluid was a prerequisite for the development of the tubular epithelial cell changes typically seen in nephrotic patients.


PMID: 10504513

DOI: 10.1046/j.1523-1755.1999.00655.x

Other references

Jesse, E.V.; Johnson, A.C.J.; Paul, A.B.; French, B.C.; Henderson, D.R.; Ward, R.W., 1982: Marketing efficiency and Federal Marketing Programs. In: Proceedings AAEA Meeting August, 1982. The first paper (pp.909-915, discussed pp.924-925) looks at USDA inspection, grading and standardization programmes and at the growing practice of the USDA of charging fees for information disseminated by its statistical, marketing and economic re...

Mendes, A.Martins, 1997: African horse-sickness. A diagnostic mistake commited after more than one century. A diagnostic mistake committed after more than one century, induced the existence of African Horse-Sickness in Angola. The author noticed the fact when he was doing historical research. African Horse-Sickness was not diagnosed in Angola so far.

Simmons, M.S.; Sivaborvorn, K., 1979: Effects of chlorinated organics from wastewater treatment on algal growth. Bulletin of Environmental Contamination and Toxicology 23(6): 766-773

Abu-Hayyeh, S.; Eddleston, J.; Murdoch, J.N.; Tham, M.; Copp, A.J.; Stanier, P., 1998: Linkage mapping of Lims1l, the murine homolog of the human LIM domain gene PINCH, to mouse chromosome 10. The human LIM domain gene LIMS1 was used to identify a mouse homolog. The resulting mouse sequence was used to identify a polymorphism by SSCP analysis. Linkage studies performed in the EUCIB backcross placed Lims1l on the proximal portion of mous...

Carpinter, P.J., 1979: Prospects for a professional surf life saving service. Recent techniques which emphasize individual instead of team methods allow for control of greater numbers of bathers by fewer people. The modest increase in demand forecast for life savers by the New Zealand bathers will not therefore be beyond th...

Caraceni, A.; Nanni, O.; Maltoni, M.; Piva, L.; Indelli, M.; Arnoldi, E.; Monti, M.; Montanari, L.; Amadori, D.; D.C.nno, F., 2000: Impact of delirium on the short term prognosis of advanced cancer patients. Italian Multicenter Study Group on Palliative Care. The objective of this study was to evaluate the impact of delirium on the survival of advanced cancer patients also assessed with a validated prognostic score (the palliative prognostic [PaP] score). The study population was a prospective multicen...

Evans, W.M.R., 1962: Hybrid vigour in pigs. Agriculture 68(12): 638-640

Pillai, V.G., 1953: Using long rhizomes for cardamom planting. In an experiment at the Cardamom Research Station, Singampatti, the use as planting material of long (8 in.) rhizomes resulted in more shoots per clump, earlier bearing and a larger net return than when short (1 in.) rhizomes were used.

Gillanders, W.R.; Buss, T.F., 1993: Access to medical care among the elderly in rural northeastern Ohio. Conventional wisdom holds that the elderly living in rural areas suffer poor health and have limited access to health care compared with their urban peers. The relation between poor health and limited access, however, has yet to be adequately defi...

Breddin, H., 1956: Tektonische Gesteins-deformation im Karbongurtel Westdeutschlands und Sud-Limburgs. Zeitschrift der Deutschen Geologischen Gesellschaft, 107: 231-260