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Efeito da Forca e da Velocidade de Compressao sobre as Propriedades de Comprimidos contendo alta Concentracao de Extrato Seco Vegetal


, : Efeito da Forca e da Velocidade de Compressao sobre as Propriedades de Comprimidos contendo alta Concentracao de Extrato Seco Vegetal. Acta Farmaceutica Bonaerense 22(2): 147-154

The aim of this work was to obtain tablets containing high-dose of spray-dried extracts from Maytenus ilicifolia. The tablets were prepared by direct compression and cellulose microcrystalline, colloidal silicon dioxide and magnesium stearate were used as excipients. The influence of compression force and machine speed on the tablets hardness, disintegration time and friability were studied by response surface methodology. Mathematical models were fitted to experimental data and validated.

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