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Effect analysis of combined Irisiquinone and radiotherapy for middle and late stage nasopharyngeal cancer


, : Effect analysis of combined Irisiquinone and radiotherapy for middle and late stage nasopharyngeal cancer. Zhongguo Zhongliu Linchuang 28(6): 439-440, Jun

Objective: To evaluate the radiosensitizing effect of Irisquinone combined with radiotherapy. Methods: Out-irradiation of 60Co-gamma including primary nasopharyngeal cancer (PNC), DT 68Gy, cervical metastatic lymph nodes DT 60apprx72Gy or preventive irradiation DT40Gy were used. Irisquinone 110mg qd or bid orally was given one day prior to the radiotherapy and it was continued until the end of irradiation. Results: In the treatment group, the PR and CR of PNC were 66.6%, 97.7%, and those of metastatic cervical nodes were 69.2%, 91.3%, while in the control group, PR and CR of PNC and metastatic cervical nodes were 42.9%, 71.3% and 48%, 60% respectively. In comparison, the PR and CR of the treatment group were higher than those in the control group. Conclusion: The result showed that Irisqinone has significant radiosensitizing effects on nasopharyngeal cancer.

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