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Effect of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on human serotonergic cells

, : Effect of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on human serotonergic cells. Neurochemical Research 25(6): 837-843

The tryptamine-derived dopaminergic neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline ('TaClo'), which was found to occur in humans after intake of the hypnotic chloral hydrate, was also shown to strongly disturb serotonergic cells. Incubation experiments using the human serotonergic cell line JAR clearly revealed TaClo to significantly reduce serotonin (5-HT) uptake (IC50 = 59 muM) and to induce a distinct loss of cellular viability at increasing TaClo concentrations.


PMID: 10944002

Other references

Koźmińska-Kubarska, A., 1976: Adverse effects of topically applied corticosteroids. Przeglad Dermatologiczny: 509-513

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Neumann, R.W., 1986: Calculating southwestern ponderosa pine site index with an HP-41 calculator. The program, PPSI, is described and listed with an example.

Grobov, O.; Shabanov, M., 1979: Effect of climatic factors on mite Varroa jacobsoni Oudemans, 1904. Doklady Bolgarskoi akademii nauk = Comptes rendus de l'Academie bulgare des sciences2(12): 1701-1703

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