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Effect of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on human serotonergic cells


, : Effect of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on human serotonergic cells. Neurochemical Research 25(6): 837-843

The tryptamine-derived dopaminergic neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline ('TaClo'), which was found to occur in humans after intake of the hypnotic chloral hydrate, was also shown to strongly disturb serotonergic cells. Incubation experiments using the human serotonergic cell line JAR clearly revealed TaClo to significantly reduce serotonin (5-HT) uptake (IC50 = 59 muM) and to induce a distinct loss of cellular viability at increasing TaClo concentrations.

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PMID: 10944002


Other references

Koźmińska-Kubarska, A., 1976: Adverse effects of topically applied corticosteroids. Przeglad Dermatologiczny: 509-513

Garrone, O.; Gasco, M.; Smith, P.; Syed, N.; Occelli, M.; Numico, G.; Comino, A.; Fea, E.; Farrell, P.; Crook, T., 2016: Methylation-dependent transcriptional silencing of Dab2 is a common early event in human tumorigenesis and predicts metastasis. NlmCategory="UNASSIGNED">9536 Background: Using pharmacological reversal of methylation, we identified Dab2 as a gene whose expression is silenced by methylation in squamous and breast carcinoma cell lines. We subsequently used methyl...

Melvin, R.G.; Andrews, M.T., 2010: Torpor induction in mammals: recent discoveries fueling new ideas. When faced with a harsh climate or inadequate food, some mammals enter a state of suspended animation known as torpor. A major goal of torpor research is to determine mechanisms that integrate environmental cues, gene expression and metabolism to...

Knowler, S.P.; v/d Berg, H.; McFadyen, A.; L.R.gione, R.M.; Rusbridge, C., 2016: Inheritance of Chiari-Like Malformation: Can a Mixed Breeding Reduce the Risk of Syringomyelia?. Canine Chiari-like malformation (CM) is a complex abnormality of the skull and craniocervical junction associated with miniaturization and brachycephaly which can result in the spinal cord disease syringomyelia (SM). This study investigated the in...

Szarek, W.A.; Martin, O.R.; Rafka, R.J.; Cameron, T.S., 1985: Structure sweetness relationships for fructose analogs 2. synthesis and properties of 1 6 dihydroxy 2 hexanone a simple analog of the ketohexoses and x ray structure determination of the corresponding dianhydrides. Labile 1,6-dihydroxy-2-hexanone (4) was prepared from the corresponding triol by selective di-O-tritylation, Collins oxidation and careful detritylation of the resulting keto compound under mild, acidic conditions. As shown by its 1H NMR and 13Cr...

Gianotti, L.R.R.; Faber, P.L.; Schuler, M.; Pascual-Marqui, R.D.; Kochi, K.; Lehmann, D., 2008: First valence, then arousal: the temporal dynamics of brain electric activity evoked by emotional stimuli. The temporal dynamics of the neural activity that implements the dimensions valence and arousal during processing of emotional stimuli were studied in two multi-channel ERP experiments that used visually presented emotional words (experiment 1) an...

Li, T.C.; Saravelos, H.; Richmond, M.; Cooke, I.D., 1997: Complications of laparoscopic pelvic surgery: Recognition, management and prevention. Laparoscopic surgery has many advantages but it is not without complications. The complexity of the surgery significantly influences the complication rate. Laparoscopic surgeons ought to be aware of the possible complications and how they could be...

Neumann, R.W., 1986: Calculating southwestern ponderosa pine site index with an HP-41 calculator. The program, PPSI, is described and listed with an example.

Grobov, O.; Shabanov, M., 1979: Effect of climatic factors on mite Varroa jacobsoni Oudemans, 1904. Doklady Bolgarskoi akademii nauk = Comptes rendus de l'Academie bulgare des sciences2(12): 1701-1703

Geggel, H.S.; Maza, C.E., 1990: Anterior stromal puncture with the Nd:YAG laser. A simple and consistent puncture of the anterior stroma was created with the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser in a rabbit model. Varying energy levels were tested, and settings at 2.0 mJ produced well-formed anterior stromal breaks...