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Effect of 2 weeks of theophylline on glucose counterregulation in patients with type 1 diabetes and unawareness of hypoglycemia


, : Effect of 2 weeks of theophylline on glucose counterregulation in patients with type 1 diabetes and unawareness of hypoglycemia. Clinical Pharmacology and Therapeutics 74(1): 77-84

Background and objective: A single dose of theophylline improves hypoglycemia unawareness in type 1 diabetic patients. Prolonged theophylline use is, however, associated with emergence of tolerance. This study investigated whether prolonged use of theophylline retains efficacy for counterregulatory defects in patients with type 1 diabetes and hypoglycemia unawareness. Methods: Experiments were performed with 12 subjects with type 1 diabetes and hypoglycemia unawareness. All subjects participated in a crossover study of 2 randomly scheduled 15-day study periods during which 250 mg theophylline twice daily or matching placebo was used. On the final day of each period, hyperinsulinemic (360 pmol cntdot m-2 cntdot min-1) hypoglycemic (5.0, 3.5, 2.5 mmol cntdot L-1) glucose clamps were used to assess counterregulatory and cardiovascular responses. Results: Under normoglycemic conditions, there were no differences between theophylline and placebo. Under hypoglycemic conditions, theophylline enhanced responses of growth hormone, symptoms, heart rate, and pulse pressure (all P < .05), induced sweating at higher plasma glucose levels (P = .039), and reduced exogenous glucose requirements (P = .018). Hypoglycemia-induced responses of epinephrine, norepinephrine, and cortisol were not enhanced by theophylline. Conclusions: Prolonged use of theophylline has a sustained effect on cardiovascular, metabolic, and symptom responses to hypoglycemia in patients with type 1 diabetes and hypoglycemia unawareness. Whether these results translate into clinical benefit remains to be determined.

US$19.90

PMID: 12844138

DOI: 10.1016/S0009-9236(03)00093-6


Other references

Hladikova J.; Houdkova Z.; Skrivan P., 1986: Geochemistry of river bottom sediments under the influence of human activity. Acta Montana 74: 101-115

Ostrovskii, Y.M.; Gorenshtein, B.I., 1967: Intensity of thiamine stock renewal and transketolase activity in tissues. Renewal of stored thiamine in various tissues of albino rats given S35 -thiamine as the only source of the vitamin was investigated. Substitution of unlabeled by labeled thiamine in liver, kidneys, skeletal muscles and spleen was completed by 5 -8...

Anonymous, 1953: NEW YORK Academy of Sciences; new members. Transactions of the New York Academy of Sciences 15(3): 86-87

Robinson, G.H.; E.A., 1961: Soil survey of Grant County, Wisconsin. U S Dept Agric Soil Conserv Serv Soil Surv 1951(10): 1-98

Hainaut, P.; Jaumotte, C.; Verhelst, D.; Wallemacq, P.; Gala, J.L.c; Lavenne, E.; Heusterspreute, M.; Zech, F.; Moriau, M., 2002: Hyperhomocysteinemia and venous thromboembolism: A risk factor more prevalent in the elderly and in idiopathic cases. Fasting plasma homocysteine level and the related clinical findings were analysed in 240 consecutive patients with venous thromboembolism. Hyperhomocysteinemia, defined as a plasma level above 20 micromol/l (corresponding to the percentile 95th in...

Miyagi, Y., 1966: Symposium on the open negative syndrome. 2. Formation of the open negative cavity during the course of original treatment and the fate of the cavity. Kekkaku 41(8): 375-378

Maione M.; Papageorgiou J.; Cordella M.; Scoccianti L.; Franchi A.; Magni R., 1986: Contrast sensitivity in diabetics comparison between psychophysical and evoked potential methods. Contrast sensitivity response were examined in diabetic subjects with and without a retinopathy. The relationship between psychophysical and evoked potential methods was studied. Data from each group of diabetic patients were compared with the dat...

Halbach, T.; Brennan, T.H.lbach, D., 1990: Home yard waste chippers. Minnesota Extension Service factsheets: (NR-FS-3949)

Olson, L.E.; Merker, M.P.; Patel, M.K.; Bongard, R.D.; Daum, J.M.; Johns, R.A.; Dawson, C.A., 2000: Cyanide increases reduction but decreases sequestration of methylene blue by endothelial cells. The mechanisms of endothelial cell transplasma membrane electron transport (TMET) have not been completely identified. Redox probes such as methylene blue (MB) can be useful tools, but the complexity of their disposition upon exposure to the cells...

Yang, B., 2003: Industry Trends: Nonprofit biotechnology companies: Friend or foe to for-profit pharmaceutical business?. Discovery Medicine 3(18): 12-12