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Effect of 2',4'-dichlorobenzamil hydrochloride, a Na+-Ca2+ exchange inhibitor, on human spermatozoa

, : Effect of 2',4'-dichlorobenzamil hydrochloride, a Na+-Ca2+ exchange inhibitor, on human spermatozoa. European Journal of Pharmacology 418(1-2): 153-155, 20 April

The present study is aimed to investigate the contact spermicidal efficacy of 2',4'-dichlorobenzamil hydrochloride (DBZ), a Na(+)-Ca(2+) exchange inhibitor, on ejaculated human spermatozoa. The drug produced a dose- and time-dependent spermicidal action on human spermatozoa. A concentration of 4 mM produced total loss of sperm viability within 1 min of addition to total semen. On the other hand, a similar action on spermatozoa separated from semen was noted at 0.5 mM concentration. The loss of spermatozoal viability was accompanied with an increase in intracellular Ca(2+). Sperm revival testing with glucose suggested a spermicidal rather than a spermiostatic action.


PMID: 11334878

DOI: 10.1016/s0014-2999(01)00892-5

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