+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of boron supplementation of pig diets on the production of tumor necrosis factor-alpha and interferon-gamma

, : Effect of boron supplementation of pig diets on the production of tumor necrosis factor-alpha and interferon-gamma. Journal of Animal Science 81(10): 2552-2561

Two experiments were conducted to determine the effects of dietary B on the production of cytokines following an endotoxin challenge. In both experiments, pigs were obtained from litters generated from sows fed low-B (control) or B-supplemented (5 mg/ kg, as-fed basis) diets. In Exp. 1 and 2, 28 and 35 pigs, respectively (21 d old), remained with their littermates throughout a 49-d nursery phase and were fed either a control or B-supplemented diet. In Exp. 1, 12 pigs per treatment were moved to individual pens at the completion of the nursery phase and fed their respective experimental diet. On d 99 of the study, pigs were injected with 150 microg of phytohemagglutinin (PHA) to evaluate a local inflammatory response. Pigs receiving the B-supplemented diet had a decreased (P < 0.01) inflammatory response following PHA injection. Peripheral blood monocytes were isolated from six pigs per treatment on d 103 and cultured in the presence of lipopolysaccharide (LPS) to determine the effect of dietary B on tumor necrosis factor-alpha (TNF-alpha) production from monocytes. Isolated monocytes from pigs that received the B-supplemented diet had a numerically greater (P = 0.23) production of TNF-alpha. In Exp. 2, pigs were group housed with their littermates following the nursery phase for 43 d, after which 10 pigs per treatment were moved to individual pens. In Exp. 1 and 2, pigs were assigned randomly within dietary treatment to receive either an i.m. injection of saline or LPS on d 117 and d 109, respectively. The dose of LPS in Exp. 1 and 2 was 100 and 25 microg of LPS/kg of BW, respectively. In Exp. 1, serum TNF-alpha was increased (P < 0.01) at 2 h and tended to be increased (P < 0.11) at 6 and 24 h after injection by dietary B; however, only numerical trends existed for a B-induced increase in TNF-alpha in Exp. 2. Serum interferon-gamma (IFN-gamma) was increased (P < 0.01) at 6 h and tended to be increased (P < 0.08) at 24 h after injection in Exp. 1. In Exp. 2, dietary B also numerically increased IFN-alpha. These data indicate that dietary B supplementation increased the production of cytokines following a stress, which indicates a role of B in the immune system; however, these data do not explain the reduction in localized inflammation following an antigen challenge in pigs.


PMID: 14552383

Other references

McCourt, C.; Dessie, S.; Bradley, A.Marie.; Schwartz, J.; Brard, L.; Dizon, D.S., 2009: Is there a taxane-free interval that predicts response to taxanes as a later-line treatment of recurrent ovarian or primary peritoneal cancer?. International Journal of Gynecological Cancer 19(3): 343-347

Brandt, C.; Matrosov, V.; Petermann, K.; Huber, Günter., 2011: In-band fiber-laser-pumped Er:YVO₄ laser emitting around 1.6 μm. Efficient laser operation at wavelengths around 1.6 μm is demonstrated in Er (1.1 at. %):YVO₄. The crystal is in-band pumped at 1536 nm by a fiber laser, resulting in a maximum slope efficiency of 57.9% with respect to the absorbed pump pow...

Motomura, Isao, 1931: On the induction of the medullary plate in Hynobius. The "Spemann effect" was studied in the eggs of the Japanese urodele, H. unnangm Tago. Pieces of the dorsal lips of early. gastrulae were inserted, inside out, into the blastocoeles of host gastrulae of the same age. In 15 cases secondar...

Morrison-Silverberg, S.A.; Jesty, J., 1981: The role of activated factor X in the control of bovine coagulation factor VII. Journal of Biological Chemistry 256(4): 1625-1630

Crouch, H.B.; Becker, E.R., 1931: Three species of coccidia from the woodchuck, Marmota monax. Eimeria monacis* Fish (described), E. perforoides* (p. 128), and E. os* (p. 128), all from feces or cecal contents of woodchucks taken near Ames, Iowa.

van der Zee, R.; Welling, G.W., 1985: Detection of sendai virus protein by reversed-phase high-performance liquid chromatography combined with immuno-chromatography. Reversed-phase high-performance liquid chromatography (RP-HPLC) was applied to the detection of Sendai virus F2 protein. Immunoaffinity chromatography was used prior to RP-HPLC to increase the specificity. With this combined method, the presence o...

Krause, K.J., 2004: Cost-benefit analysis of electron beam CT as a life insurance coronary disease risk assessment tool. Electron beam CT (EBCT) or ultrafast CT is a diagnostic imaging technique that can identify calcium deposits within coronary arteries. Intra-coronary calcium is associated with coronary artery atherosclerosis. EBCT imaging has been advocated as a...

Thorarinsson Sigurdur, 1957: The joekulhlaup from the Katla area in 1955 compared with other joekulhlaups in Iceland. Enormous but short-lived subglacial discharges of water (joekulhlaups) of the volcano-glacial type, such as those which precede eruptions of Katla volcano, Iceland, differ from limnoglacial joekulhlaups (discharges from subglacial lakes) by the ve...

Fromowicz, K.K.; Liwszyc, S.; Osterczy, Z.; Polatynska, W.Cawowicz, J., 1956: Role of the neurovegetative factor in the pathogenesis of renal inflammation, and attempts at management with phenothiazine derivatives. Das Deutsche Gesundheitswesen 11(30): 1012-1016

Fluck, H., 1952: A new reaction to demonstrate the presence of Rheum rhaponticum roots and related species in true medical rhubarb. With phosphomolybdic acid in sulfuric acid the roots and rhizome of R. raphonticum, R. undulatum, R. compactum and R. emodi give a deep blue coloration; true rhubarb gives no more than a yellow-green or olive-green color.