+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of chronic ethanol consumption on protective T-helper 1 and T-helper 2 immune responses against the parasites Leishmania major and Strongyloides stercoralis in mice

, : Effect of chronic ethanol consumption on protective T-helper 1 and T-helper 2 immune responses against the parasites Leishmania major and Strongyloides stercoralis in mice. Alcoholism Clinical & Experimental Research 25(4): 571-578, April

Background: Chronic alcohol consumption has been associated with significant increases in the prevalence of infectious diseases, and it has been suggested that these increases are caused by a direct effect of ethanol on the immune response. The objective of this study was to determine whether chronic ethanol consumption would affect the development of protective immunity to Leishmania major, which is controlled by the T-helper 1 (Th1) subset of CD4 cells, and Strongyloides stercoralis, which is controlled by the Th2 subset. Methods: Mice were fed ethanol-containing liquid diet (25% ethanol-derived calories), liquid isocaloric diet without ethanol, or solid chow and then exposed to either of the two parasites. The ability of the mice chronically consuming alcohol to eliminate the infections was determined, as were the levels of parasite-specific humoral and cellular immune responses. Results: Mice chronically consuming alcohol were capable of eliminating both of these infections in a manner identical to the control mice. In addition, splenocytes from mice chronically consuming alcohol infected with L. major produced nitric oxide at the same levels as in control mice. Antibody responses were altered in a manner suggesting an increase in Th2 immunity and a decrease in Th1 immunity in the mice chronically consuming alcohol. In mice chronically consuming alcohol that were infected with S. stercoralis, eosinophils migrated to the parasite's microenvironment, and antibodies were produced at levels equivalent to those seen in control mice. Conclusions: Mice maintained on an ethanol-containing liquid diet had some alteration in their ability to produce Th1 and Th2 immune responses yet were capable of generating unimpaired protective Th1 and Th2 responses.


PMID: 11329498

DOI: 10.1111/j.1530-0277.2001.tb02252.x

Other references

Papanicolaou, A.C.; Castillo, E.; Breier, J.I.; Davis, R.N.; Simos, P.G.; Diehl, R.L., 2003: Differential brain activation patterns during perception of voice and tone onset time series: A MEG study. Evoked magnetic fields were recorded from 18 adult volunteers using magnetoencephalography (MEG) during perception of speech stimuli (the endpoints of a voice onset time (VOT) series ranging from /ga/ to /ka/), analogous nonspeech stimuli (the end...

Yoshikawa, T.; Shibuya, H.; Kaneno, S.; Toru, M., 1991: Blockade of behavioral sensitization to methamphetamine by lesion of hippocampo-accumbal pathway. The present studies were carried out to explore a role of the hippocampal efferents in the development of the locomotor augmentation induced by repeated methamphetamine administrations. For this purpose, electrolytic lesions of either the dorsal f...

Gasińska, T.; Rozek-Lesiak, K.; Harbut-Gryłka, A., 1979: Effect of hydrochlorothiazide on various parameters of calcium and phosphate metabolism in patients with increased bone resorption caused by malignant metastases to the skeleton. Polski Tygodnik Lekarski 34(38): 1499-1502

D.S.efano L.; D'amelio V.; Musmeci M.T.; Mezzasalma E., 1972: Characterization of the naphthyl amidases from chicken red cells. Bollettino di Zoologia 39(4): 612

Michels, R., 1976: Professional ethics and social values. International Review of Psycho-Analysis 3(4): 377-384

Meszoly, G.; Hodosy, S.; Szurke, J., 1965: Results obtained in Hungary in the breeding and comparative investigation of tomato varieties resistant to leaf mould. The distribution of Cladosporium fulvum, its economic importance, biology and control, and breeding tomatoes abroad and in Hungary for resistance to leaf mould are reviewed. Simple and complex specific hybrids were produced using Lycopersicon escu...

Burstein, H.J.; Demetri, G.D.; Mueller, E.; Sarraf, P.; Spiegelman, B.M.; Winer, E.P., 2003: Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study. Purpose. To evaluate the therapeutic effects of the peroxisome proliferator-activated receptor (PPAR) gamma activating ligand, troglitazone, in patients with refractory metastatic breast cancer. Experimental design. Patients with advanced breast c...

Gildea, J.J.; Harding, M.A.; Theodorescu, D., 2000: N-Cadherin expression in bladder cancer progression. Proceedings of the American Association for Cancer Research Annual Meeting (41): 162, March

Wasserman Evgeny A.; Yuen David A.; Rustad James R., 1993: Molecular dynamics study of the transport properties of perovskite melts under high temperature and pressure conditions. The transport properties of perovskite melts by molecular dynamics in the temperature range from 3000 to 6000 K and pressure range from 5.1 to 78 GPa were studied. Shear viscosities, coefficients of self-diffusion, infrared absorption spectra, and...

Malicki, A.; Jarmoluk, A.; Bruzewicz, S., 2004: Effect of sodium lactate used alone or in combination with lysozyme on the physico-chemical and microbiological properties of steamed sausage stored under the refrigeration. The purpose of this paper was to evaluate the effects of the addition of 2% sodium lactate, alone or in combination with 200 ppm lysozyme, on the microbial status, stability and physicochemical properties of steamed sausages. Lactate, used separat...