geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of organotins on human aromatase activity in vitro


, : Effect of organotins on human aromatase activity in vitro. Toxicology Letters (Shannon) 126(2): 121-130, January 25th

The interaction between the human aromatase enzyme and some organotins was investigated. Tributyltin (TBT) at 12 and 59 muM and dibutyltin at 74 muM inhibited aromatase activity in vitro but monobutyltin and tri-, di- and monooctyltins were without effect. In four separate kinetic studies of aromatase, the Km(app) for testosterone was 0.24, 0.21, 0.16 and 0.24 muM. TBT inhibited aromatase activity by causing the Km(app) to be increased without affecting the Vmax, indicative of competitive inhibition. Slope and intercept replots confirmed the effect of aromatase on the Km(app). Slope replots from three separate kinetic studies provided Ki values for TBT of 64.5, 40.9 and 37.3 muM. Consequently, TBT is a competitive inhibitor of human aromatase with a Ki approximately 300-fold the Km(app) value.

US$19.90

DOI: 10.1016/s0378-4274(01)00451-9


Other references

Cohen, A-Lisa.; Gordon, A.; Jaudas, A.; Hefer, C.; Dreisbach, G., 2016: Let it go: the flexible engagement and disengagement of monitoring processes in a non-focal prospective memory task. NlmCategory="UNASSIGNED">Remembering to perform a delayed intention is referred to as prospective memory (PM). In two studies, participants performed an Eriksen flanker task with an embedded PM task (they had to remember to press F1 i...

Sasakawa N.; Nakaki T.; Yamamoto S.; Kato R., 1987: Inositol trisphosphate accumulation by high potassium stimulation in cultured adrenal chromaffin cells. Febs Letters 223(2): 413-416

Doby J.M.; Piedade Guerreiro J.; Drozdz J., 1971: Geographic distribution of angiostrongylus dujardini new record parasitic nematode of small wild rodents presence in portugal. Anais da Escola Nacional de Saude Publica e de Medicina Tropical 5(1-2): 59-60

Valentini, R.; Matteucci, G.; Dolman, A.J., 2000: Respiration as the main determinant of carbon in European forests. Net ecosystem carbon exchange data, collected between 1996 and 1998 from 15 European forests, confirm that many European forest ecosystems act as carbon sinks. In general, ecosystem respiration will determine the net ecosystem carbon exchange. Add...

Krüger, H.M.; Collins, Térèse.; Englitz, B.; Cavanagh, P., 2016: Saccades create similar mislocalizations in visual and auditory space. Orienting our eyes to a light, a sound, or a touch occurs effortlessly, despite the fact that sound and touch have to be converted from head- and body-based coordinates to eye-based coordinates to do so. We asked whether the oculomotor representat...

Mathews, L.W.; Vale, W.W.; Tsuchida, K., 2000: Recombinant vertebrate activin receptors. In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, a hydrophobic, trans-memb...

Picard M.D.ne; Hulen J.B., 1969: Parting lineation in siltstone. Red Peak formation (early? Triassic), Wyoming.

Nassau K., 1975: The origins of color in gems and minerals, Part 2. Gems and Gemology 15(1): 2-11

Labenz, J.; Börsch, G., 1994: Is ulcer disease an infectious disease?. Deutsche Medizinische Wochenschrift 119(43): 1488-1489

Snyder G.; Hymer W.C., 1971: Divalent cations and growth hormone synthesis. American Zoologist 11(4): 656