+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of ACTH-induced hypertension in the pregnant ewe

, : Effects of ACTH-induced hypertension in the pregnant ewe. Journal of Cardiovascular Pharmacology 34(6): 818-823

Adrenocorticotropic hormone (ACTH; 5 microg/kg/ day) infused into 10 pregnant ewes (gestation age, 127-139 days) for 72 h caused an increase in arterial pressure within 1-2 h (p < 0.05), which was sustained for the rest of the experiment. Cardiac output was increased at 24 h (p < 0.05). Total peripheral resistance did not change. There were no changes in four pregnant ewes infused with 0.15 M saline at the same rate for 72 h. In ACTH-treated pregnant ewes, a relation between arterial pressure and plasma renin activity observed in nontreated pregnant ewes (r = 0.71; p = 0.0005) was no longer evident. Compared with nonsurgical pregnant ewes, total angiotensin II (Ang II)-receptor density in the uterine artery was decreased in ewes that had previously had surgery (p = 0.015) and further reduced in ACTH-treated ewes (p < 0.0005). This was due to a reduction in the AT2-receptor density, which was inversely related to plasma cortisol levels (r = 0.73; p < 0.03). AT1-receptor density and the affinities of the AT1 and AT2 receptors were unchanged. The correlation between plasma cortisol and AT2-receptor density in uterine blood vessels may partly explain why these receptors are downregulated after surgery.


PMID: 10598125

Other references

Medvedeva, T.N.; Matiashova, T.N.; Lenskikh, G.V.; Romanova, I.B., 1985: Production of extracellular higher fatty acids by yeasts grown on hexadecanoic acid. Production of exocellular higher fatty acids by Candida yeasts was studied during their growth in a mineral medium with hexadecane. The qualitative and quantitative composition of exocellular higher fatty acids was investigated during cultivation...

Arya, S.C., 2001: Vanishing polio and emerging acute flaccid paralysis in India. National Medical Journal of India 13(3): 163-163

Al-Shemari, H.; Bossé, Y.; Hudson, T.J.; Cabaluna, M.; Duval, M.; Lemire, M.; Vallee-Smedja, S.; Frenkiel, S.; Desrosiers, M., 2008: Influence of leukotriene gene polymorphisms on chronic rhinosinusitis. Background: Chronic rhinosinusitis (CRS) is increasingly viewed as an inflammatory condition of the sinonasal mucosa interacting with bacteria and/or fungi. However, factors conferring susceptibility to disease remain unknown. Advances in genomic...

Delack, S., 2011: NASN's voice on both sides of the aisle. Nasn School Nurse 26(2): 67-67

Murley, D.; Hovorka, R.; Young, M.A.; Patel, J., 1995: Reproducibility of parameter estimates from the two compartment minimal model of labelled IVGTT. Diabetologia 38(SUPPL 1): A128

Froelich, Adrienne, 2003: Third Time a Charm for NSF's National Ecological Observatory Network?. The writer discusses the National Academy of Sciences panel's recent report on plans by the National Science Foundation (NSF) to develop a National Environmental Observatory Network (NEON). She reflects that the report criticized the NSF&apos...

Leblond, A.; Sandoz, A.; Lefebvre, G.; Zeller, H.; Bicout, D.J., 2006: Remote sensing based identification of environmental risk factors associated with West Nile disease in horses in Camargue, France. Geographic information system and remote sensing technologies were used to identify landscape features associated with risk of West Nile virus transmission as defined by the presence of confirmed horse cases. SPOT-4 images of Camargue area were u...

Murad M., 1972: Hemodynamics of tricuspid stenosis. Folha Medica 65(3): 501-512

Piper, Nick, 2013: Audiencing Jamie Oliver Embarrassment, voyeurism and reflexive positioning. This paper explores audience engagements with popular television food media via a focus on UK based celebrity chef Jamie Oliver. One series, <italic>Jamie s Ministry of Food</italic> (<italic>JMOF</italic>) is argued to for...

Munoz Armas, S.; Anselmi, G., 1972: Atresia of the venous auriculoventricular orifice. Archivos del Instituto de Cardiologia de Mexico 42(6): 932-950