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Effects of experimental cortical seizures on respiratory motor nerve activities in piglets

, : Effects of experimental cortical seizures on respiratory motor nerve activities in piglets. Journal of Applied Physiology 86(6): 2052-2058

Airway obstruction at the level of the larynx causes respiratory insufficiency during experimental seizures in spontaneously breathing, anesthetized piglets (T. E. Terndrup and W. E. Fordyce, Pediatr. Res., 38: 61-66, 1995). To investigate further the neural mechanisms of this obstruction, the activities of the phrenic nerve (PH) and the recurrent laryngeal motor branches to the thyroarytenoid (TA) and posterior cricoarytenoid (PCA) muscles were analyzed in 11 anesthetized, vagotomized, paralyzed, and ventilated piglets. After a control recording period, seizures were induced by subcortical penicillin G injections. Compared with baseline conditions, nerve activities became irregular during seizures. Extraneous TA bursts during PH activation were evident in all piglets during seizures. During ictal phases of seizures, the peak integrated activities of the PH and the expiratory component of the PCA, but not TA or inspiratory PCA activities, were significantly decreased compared with interictal phases. During seizures, a significant delay in the onset of the inspiratory component of PCA activation with respect to the onset of the PH was observed. This study helps to explain respiratory impairment during cortical seizures by providing evidence of impaired timing of activation of laryngeal dilator mechanisms and coordination with those activating the diaphragm. Cyclical PH inhibition during high-intensity cortical discharges may provide a secondary mechanism producing respiratory insufficiency during seizures.


PMID: 10368373

Other references

Danko J.; Kadlec E.; Rejl L., 1983: Methods of geophysical prospecting for buried ore deposits in the Jeseniky Mts. Sbornik Geologickych Ved Uzita Geofyzika = Journal of Geological Sciences

Hussain, M.A.; Mishra, R.; Kansal, S.; Mishra, C.P.; Jha, S.K.; Hasan, H., 2013: Treatment seeking in reproductive age women with RTIs/STIs: a community based cross-sectional study. The socio-cultural and economic contexts in developing countries influence the epidemiology or STIs and helps in making them an important public health priority. This study was carried out to explore the health care seeking pathway of the women su...

Bemis, W.P., 1962: Wild gourds key to pumpkin and squash Improvement. A short general account is given of a crossing programme undertaken to elucidate barriers to interspecific hybridization within the genus Cucurbita.

Calpena, A.C.; Escribano, E.; San Martin, H.; Lauroba, J.; Obach, R.; Domenech, J., 2000: Influence of the formulation on the in vitro transdermal penetration of sodium diclofenac. Evaluation of the topical and systemic anti-inflammatory activity in the rat. A study on the transdermal permeation through human skin was performed with a series of 6 semisolid formulations (A-F) containing 1% sodium diclofenac (CAS 15307-79-6) (w/w). A commercially available drug preparation was tested as a reference. Bas...

Batten T.F.C., 1985: Direct neurosecretory innervation of the teleost pituitary characterization by electron microscopic immunocytochemistry. Kobayashi, H , H A Bern And A Urano (Ed ) Neurosecretion And The Biology Of Neuropeptides: Ninth International Symposium on Neurosecretion, Susono-Shi, Japan Xviii+544p Springer-Verlag: Secaucus, N J , Usa; Berlin, West Germany; Japan Scientific Societies Press: Tokyo, Japan Illus 130-131

Hudis, C.A.; Hainsworth, J.D.; Perez, E.A.; Macciocchi, A., 2003: Palonosetron is more effective than ondansetron/dolasetron in preventing chemotherapy-induced nausea and vomiting in patients with breast cancer Combined results of 2 phase 3 trials. Breast Cancer Research & Treatment 82(Supplement 1): S153

Vorontsov M.P.; Mikheev V.V., 1980: Cardio vascular function in female students of a technical school. Combined effect of occupational factors on the cardiovascular function of girl students attending a school that trains opticians showed that the adaptation of adolescents to the specific conditions of production (noise, elevated ambient temperatur...

Aldridge H.D.J.N., 1987: Body accelerations during the wingbeat in six bat species the function of the upstroke in thrust generation. The kinematics and aerodynamics of hinolophus ferrumequimum, R. hipposideros, Myotis nattereri, M. mystacimus, Plecotus auritus and Eptesicus serotinus in horizontal flight at various flight speeds are described. Three kinematic patterns can be re...

Yamamoto, Kokichi, 1953: Preliminary studies on the Rotatorian fauna of Korea. The taxonomical and ecological distr. are discussed. They were collected from 16 places, which may be roughly classified into 4 regions, the eastern, northern, middle, and western. 83 spp. (including 8 vars. and 7 forms) in 10 fams. and 26 genera...

Yan, W.; Zhang, J.; Zhang, Y.; Jung, Y-Sam.; Chen, X., 2012: p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability. p73, a p53 family tumor suppressor, is expressed as TA and ΔN isoforms. Due to the role of p73 in tumor suppression and neural development, its expression and activity are tightly regulated by multiple mechanisms, including transcription and post...