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Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma


, : Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma. Allergy (Copenhagen) 58(7): 602-607, July

Background: Noninvasive surrogate markers provide valuable information on the asthmatic inflammatory process. We wished to examine the effects of low dose fluticasone/salmeterol combination on different commonly used inflammatory markers in moderate persistent asthma. Methods: Twenty-five moderate persistent atopic asthmatics were enrolled of whom 20 completed an open label study. Following an initial 4 week steroid washout period in which patients took salmeterol 50 mug dry powder inhaler 1 puff BD, they received the addition of fluticasone as fluticasone 100 mug/salmeterol 50 mug combination dry powder inhaler 1 puff BD for the next 2 weeks. Exhaled nitric oxide, spirometry, methacholine PD20, sputum/blood eosinophils and sputum/serum eosinophil cationic protein (ECP) were measured following the salmeterol only and fluticasone/salmeterol combination treatment periods. Results: Compared to salmeterol alone (i.e. after the steroid washout), the use of fluticasone/salmeterol combination conferred significant improvements (P < 0.05) in all surrogate markers of inflammation apart from serum ECP. Geometric mean fold changes were 4.3-fold/1.3-fold for sputum/blood eosinophils, 2.2-fold/1.2-fold for sputum/serum ECP, 2.3-fold for methacholine PD20 and 1.8-fold for exhaled nitric oxide. Conclusions: Surrogate markers apart from serum ECP may be used as a guide to evaluate the anti-inflammatory effects of low dose inhaled corticosteroids. Sputum markers tend to be more sensitive than blood when assessing the anti-inflammatory response.

US$19.90

PMID: 12823118

DOI: 10.1034/j.1398-9995.2003.00188.x


Other references

Visnyakov, J.; Sztojavona, E., 1968: A larvalis echinococcosis elterjedtsege a hasznos haziallatokban Bulgariaban. Hydatid cysts were present in 48% of 511 cattle in the abattoirs of Sofia and Khaskovo, Bulgaria. Most (80%) of the infected animals were older than 10 years. The observation shows an appreciable decrease in infection with hydatid cysts compared w...

Potetinova, Z.; Barbier, J-René.; Suen, T.; Dean, T.; Gardella, T.J.; Willick, G.E., 2006: C-terminal analogues of parathyroid hormone: effect of C-terminus function on helical structure, stability, and bioactivity. We have studied the effects of C-terminal group modifications (amide, methylamide, dimethylamide, aldehyde, and alcohol) on the conformation, adenylyl cyclase stimulation (AC), or binding of parathyroid hormone (hPTH) analogues, hPTH(1-28)NH2 and...

Schmoelz, W.; Sandriesser, S.; Loebl, O.; Bauer, M.; Krappinger, D., 2017: Effect of cage design, supplemental posterior instrumentation and approach on primary stability of a lumbar interbody fusion - A biomechanical in vitro study. There are various techniques and approaches for lumbar interbody fusion differing in access, cage type and type of supplemental posterior instrumentation. While a transforaminal access usually includes a hemifacetectomy, the facet joint can be pre...

Chanh, Pham Huu, 1964: Structure-activity relationship of aerosols of vanillin and of its isomers and derivatives on the isolated guinea-pig lungs. Of the 3 isomers (vanillin, orthovanillin and isovanillin) only isovanillin provokes pneumo-constriction in the isolated lung of the guinea-pig. This property seems to be due to the particular position of the methoxy function in para, and to the h...

Bruneau Denis; Gray James T., 1997: Ice flows and early deglaciation (ca 11 ka BP?) in the northeastern Ungava Peninsula, Quebec, Canada. Studies of the lithological composition and carbonate contents in the till, the glacial striations and the glacial geomorphology allowed the identification of two distinct ice flows at the northeast end of the Ungava Peninsula and in the area of t...

Hussein, H.S., 1981: Studies on the haematology of Babesia hylomysci and Babesia microti infections in mice. II. Reticulocytosis and infection rate of erythrocytes and reticulocytes. In LACA mice infected with 5 x 106 erythrocytes infected with B. hylomysci, the reticulocyte count increased progressively from 3.2% before infection to 60.4% on day 8. In mice similarly infected with B. microti the increase in reticulocyte count...

Alberti, K.G.; Sharp, G.W., 1970: Identification of four types of steroid by their interaction with mineralocorticoid receptors in the toad bladder. Journal of Endocrinology 48(4): 563-574

Justin, B.Sancon, L.; Lamotte, M.; Lamotte, B.Rrillon, S.; Grivaux, M.; Boivin, P.; Pariente, R., 1961: Gastrectomv and the endocrine glands. La Semaine des Hopitaux 37: 1398-1406

Zimmerman, D.R.; Koszewski, N.J.; Hoy, D.A.; Goff, J.P.; Horst, R.L., 2015: Targeted delivery of 1,25-dihydroxyvitamin D3 to colon tissue and identification of a major 1,25-dihydroxyvitamin D3 glycoside from Solanumglaucophyllum plant leaves. Leaves of the Solanum glaucophyllum (Sg) plant, indigenous to South America, have long been known for their calcinogenic toxicity in ruminant animals. It was determined the leaves contained glycosidic derivatives of 1,25-dihydroxyvitamin D3 (1,25D...

Brown, H.; Hunt, N.; Stein, J., 1994: 'Alarming but very necessary': Working with staff groups around the sexual abuse of adults with learning disabilities. This study focused on the knowledge of front line staff, as individuals and in groups, in relation to the sexual abuse of adults with learning disabilities and was designed to inform staff training and policy initiatives and to explore gender dyna...