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Effects of perioperative recombinant human IFN-gamma (rHuIFN-gamma) application in vivo on T cell response

, : Effects of perioperative recombinant human IFN-gamma (rHuIFN-gamma) application in vivo on T cell response. Journal of Interferon & Cytokine Research 23(3): 149-154

In spite of the well-known immunoregulatory effects of recombinant human interferon-gamma (rHuIFN-gamma), in vitro clinical trials in trauma patients remain inconclusive. In vitro studies have shown that IFN-gamma has an effect on lymphocyte responses in addition to immunomodulatory effects on the monocyte/macrophage system. To investigate the in vivo effect of rHuIFN-gamma perioperatively on lymphocyte behavior in surgical patients, we studied 46 anergic patients undergoing major surgery.


PMID: 12716487

DOI: 10.1089/107999003321532484

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