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Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis

, : Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis. Annals of Neurology 49(4): 536-540, April

Using transcranial magnetic stimulation, the effect of riluzole (RLZ) on cortical excitability was studied in patients with amyotrophic lateral sclerosis (ALS). Paired-pulse inhibition (PPI) and paired-pulse facilitation (PPF) were reduced. RLZ partially restored deficient PPI in the first of 4 consecutive 3-month periods of testing, but left PPF unchanged. These findings substantiate the view that attenuation of glutamate-related excitotoxicity is an important factor contributing to the beneficial effect of RLZ in ALS.


PMID: 11310635

DOI: 10.1002/ana.107

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