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Experimental study on assessment of left ventricular systolic function in early diabetic cardiomyopathy by Doppler tissue imaging


, : Experimental study on assessment of left ventricular systolic function in early diabetic cardiomyopathy by Doppler tissue imaging. Zhongguo Chaosheng Yixue Zazhi 19(6): 401-404

Objective: To evaluate the developmental course of left systolic ventricular function in early diabetic cardiomyopathy by Doppler tissue imaging (DTI). Methods: Cardiac function was examined with DTI in rabbits of 2, 4, 6 and 8 weeks after intravenous injection into auricular marginal vein with 65 mg/kg of streptozotocin (STZ). The motion of lateral wall and posterior interventricular septum at mitral annulus was estimated with PW-DTI. The parameters such as systolic peak velocity (Sa), preejection period (PEP), local ejection time (ET) and systolic mean velocity (Vm) of four various portions in mitral annulus were determined. The killed rabbit hearts were examined microscopically after echo cardiography at 2, 4, 6 and 8 week in respective 4 groups. Results: STZ-induced diabetic rabbits menifested the systolic dysfunction as early as at 6 weeks. Conclusions: DTI can display early systolic dysfunction of diabetic cardiomyopathy in STZ-induced diabetic rabbits without coronary disease.

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