+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Expression of group I and II metabotropic glutamate receptors in trigeminal neurons during postnatal development

, : Expression of group I and II metabotropic glutamate receptors in trigeminal neurons during postnatal development. Developmental Neuroscience 23(1): 41-54

Trigeminal motoneurons (Mo5), mesencephalic trigeminal neurons (Me5), supratrigeminal neurons (Su5), and intertrigeminal neurons (I5) are important constituents of the neural circuitry responsible for jaw movements. Glutamate neurotransmission, mediated by ionotropic and metabotropic glutamate receptors (mGluRs), is critical for the production of jaw movements. To better understand the role of mGluR-mediated modulation of these neurons during early postnatal development, we conducted a series of experiments to illustrate the ontogeny of mGluRs 1, 5 (group I) and mGluRs 2, 3 (group II) in Mo5, Me5, Su5, and I5 neurons using receptor immunohistochemistry. Results demonstrate that the temporal expression of mGluRs is differentially regulated between, and within these trigeminal nuclei. The localization of group I and II mGluRs in these nuclei suggests a role for these receptors in mediating glutamatergic neurotransmission in brainstem circuits responsible for oral-motor behaviors.


PMID: 11173926

DOI: 48695

Other references

Strasberg, S.; Johnson, E.J.; Parry, T., 2016: "Stuttering" after minor head trauma. Traumatic brain injury (TBI) is defined as impairment in brain function as a result of mechanical force. It is classified based on clinical findings using the Glasgow Coma Scale (GCS). Mild TBI is defined as GCS 14-15; moderate, 9-13; and severe,...

Ni, K.; Steger, K.; Yang, H.; Wang, H.; Hu, K.; Chen, B., 2015: Expression and role of leptin under hypoxic conditions in human testis: organotypic in vitro culture experiment and clinical study on patients with varicocele. We investigated the expression and the exact role of leptin under hypoxic conditions in the human testis. Five testes from patients treated with orchiectomy for prostate cancer were used to construct an in vitro hypoxic culture system for human te...

Clarke, R.; Combridge, MC.; Combridge, P., 1988: The diet of hen harriers roosting in the New Forest. Hampshire Bird Report. 1987 ; 1987: 78-82

Russe, O., 1960: Follow-up study results of 22 cases of operated old fractures and pseudarthroses of the scaphoid bone of the hand. Zeitschrift für Orthopadie und Ihre Grenzgebiete 93: 5-14

Nandy, S.; Chalmers-Watson, C.; Gantley, M.; Underwood, M., 2001: Referral for minor mental illness: a qualitative study. Mild depression and anxiety are common problems in general practice. They can be managed by the general practitioner (GP) alone or referred. Previous quantitative studies have shown a large variation between GPs in terms of referral behaviour. The...

Baker, R.F., 1981: Membrane deformability of metabolically depleted human red cells. The membrane deformability of metabolically depleted human red cells has been measured using a simplified technique of Nuclepore aspiration. Cells depleted in the presence of 25 microM--2 mM Ca2+ were 11.3%-15.7% less deformable than fresh cells....

Chissov, V.I.; Sidorenko, Y.S.; Starinskii, V.V.; Merabishvili, V.M.; Kovalev, B.N.; Bondarenko, V.G.; Remennik, L.V.; Shelyakina, T.V., 1995: Current problems in organization of oncological help. Voprosy Onkologii (St Petersburg) 41(2): 11-18

Zygraich, N.D.lforge, J., 1983: Simultaneous administration of live vaccines for protection against respiratory viroses in cattle. Annales de medecine veterinaire 127(1): 23-27

Holers, V.Michael.; Boackle, S.A., 2004: Complement receptor 2 and autoimmunity. Complement receptor 2 (CR2/CD21) plays a major role in the immune response by linking innate and adaptive immunity to foreign pathogens and proteins. In addition, several lines of evidence strongly support a role for CR2 in the maintenance of tole...

Burton, I.; Wilson, J.; Munn, R.E., 1983: Environmental impact assessment: National approaches and international needs. This paper examines the spread and development of 'environmental impact assessment' (EIA) since the enactment of the U.S. Environmental Policy Act on January 1, 1970, which established for the first time under any jurisdiction the formal...