geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Extracellular levels of dopamine in the nucleus accumbens in AA and ANA rats after reverse microdialysis of ethanol into the nucleus accumbens or ventral tegmental area


, : Extracellular levels of dopamine in the nucleus accumbens in AA and ANA rats after reverse microdialysis of ethanol into the nucleus accumbens or ventral tegmental area. Alcohol 29(2): 117-124, February

Ethanol is known to increase the release of dopamine in the nucleus accumbens. The question of whether this is a result of a direct or an indirect effect of ethanol on mesolimbic dopaminergic neurons was examined by investigating the extracellular levels of dopamine and its metabolites in the nucleus accumbens of alcohol-preferring AA (Alko Alcohol) and alcohol-avoiding ANA (Alko Non-Alcohol) rats after application of ethanol locally into either the nucleus accumbens or the ventral tegmental area with the use of reverse microdialysis. Application of ethanol (200, 400, or 800 mM in dialysate) into the nucleus accumbens, but not into the ventral tegmental area, temporarily increased the accumbal levels of dopamine in a dose-dependent manner. The ethanol-evoked increase in the level of extracellular dopamine was more prominent in AA rats than in ANA rats. Ethanol tended to suppress levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid. Because the concentrations of ethanol found to elevate the extracellular level of dopamine can hardly be considered pharmacologically relevant, the increase in accumbal dopamine levels after application of ethanol may be due to nonspecific membrane effects of ethanol. The findings support the suggestion that the increase in the extracellular level of dopamine in the nucleus accumbens after systemic administration of ethanol may involve other sites on dopamine neurons or even different neurotransmitter systems, rather than the action of ethanol at the mesolimbic dopaminergic terminals.

US$19.90

PMID: 12782253

DOI: 10.1016/s0741-8329(03)00017-x


Other references

Jimenez S.; E.; Llano G.; A.; Hutchins, L.M., 1966: The effects of nitrogen, potassium and boron on the growth of green-point galls of cacao. The Solutions used contained 500 or 1, 000 p.p.m. N, 150 or 300 p.p.m. K and 0.5 p.p.m. B, the 3 elements being applied either singly or in various combinations. Cacao seeds with the testas removed were soaked in the solutions and the emerging rad...

Kunze, L.S.; Fitzgerald, S.D.; Richard, A.; Balander, R.; Reed, W.M., 1996: Variations in response of four lines of ring-necked pheasants to infection with marble spleen disease virus. This study evaluated the response and susceptibility of four lines of ring-necked pheasants to infection with marble spleen disease (MSD) virus. Fifteen birds of the following lines were used: the standard ring-necked gamebird, the highly inbred j...

Staszkiewicz, J., 1993: Variability of Pinus mugo x P. sylvestris (Pinaceae) hybrid swarm in the Tisovnica Nature Reserve (Slovakia). Pinus mugo x P. sylvestris (= P. x rhaetica) hybrids from the Tisovnica peat bog reserve (Slovakia) are characterized with respect to seven morphological and anatomical features.

Petkova E.; Todorov V., 1991: Target volume and linear radioactive sources for intracavitary brachytherapy of endometrial carcinoma. European Journal of Cancer 27(SUPPL 3): S83

Marcuzzi, G.; Dalle Molle, L.; Nigro, L., 1977: Contributo alla conoscenza del popolamento animale della forbicra piana di S. Martino di Castrozza. Studi trent Sci nat (Biol): 54: 143-166

Bunker Bill J.; Klapper Gilbert, 1984: Conodont zones and correlation of the Cedar Valley-State Quarry interval of eastern Iowa. Field Trip Guidebook - Geological Society of Iowa 11: 15-18

Belani, C.P., 1993: Multimodality management of regionally advanced non-small-cell lung cancer. Seminars in Oncology 20(4): 302-314

Adams, W.H.; Digre, K.B.; Patel, B.C.K.; Anderson, R.L.; Warner, J.E.A.; Katz, B.J., 2006: The evaluation of light sensitivity in benign essential blepharospasm. PURPOSE: To test light sensitivity thresholds rigorously in patients with benign essential blepharospasm (BEB) compared with patients who have known light sensitivity (migraineurs) and to normal control subjects.DESIGN: Prospective, observational,...

Zakharov Y.; Prenant M., 1983: Erythro blastic island macrophage cultures role of culture supernatant in rat erythropoiesis. The isolation of central macrophages from erythroblastic islands (EI) permitted analysis of the role of EI macrophage factors in erythropoiesis. EI macrophage supernatant and peritoneal macrophage supernatant both had a similar effect on erythropo...

Sanchez-Criado, JE.; Mora, OA.; Gallego, A., 1989: Structure and function of the vomeronasal system - the vomeronasal organ as primary pheromone receptor in mammals. Progress in Sensory Physiology, 9: 193-222