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Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits

, : Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits. Science 294(5549): 2176-2178

Calcium (Ca2+) influx through Ca2+-permeable ion channels plays a pivotal role in a variety of neuronal signaling processes, and negative-feedback control of this influx by Ca2+ itself is often equally important for modulation of such signaling. Negative modulation by Ca2+ through calmodulin (CaM) on cyclic nucleotide-gated (CNG) channels underlies the adaptation of olfactory receptor neurons to odorants. We show that this feedback requires two additional subunits of the native olfactory channel, CNGA4 and CNGB1b, even though the machinery for CaM binding and modulation is present in the principal subunit CNGA2. This provides a rationale for the presence of three distinct subunits in the native olfactory channel and underscores the subtle link between the molecular make-up of an ion channel and the physiological function it subserves. Copyright 2001 by the AAAS.


PMID: 11739960

DOI: 10.1126/science.1063415

Other references

Schenone H.; Jacob C.; Rojas A.; Villarroel F., 1967: Trichinella spiralis infection in rattus norvegicus host from the municipal abattoir of santiago chile. Boletin Chileno de Parasitologia 22(4): 176

Felsenfeld, O.; Wolf, R.H.; Gyr, K.; Grant, L.S.; Dutta, N.K., 1973: Simultaneous vaccination against cholera and yellow fever. Lancet 1(7801): 457-458

Braccini, G.Lucca.; Natali, M.Raquel.Marçal.; Ribeiro, R.Pereira.; Mori, R.Hideo.; Riggo, R.; Oliveira, C.A.L.; Hildebrandt, Jão.Fábio.; Vargas, L., 2014: Morpho-functional response of Nile tilapia (Oreochromis niloticus) to a homeopathic complex. Homeopathy 102(4): 233-241

Lange, N.W.; Salerno, D.M.; Berger, K.; Tsapepas, D.S., 2017: Using known drug interactions to manage supratherapeutic calcineurin inhibitor concentrations. To summarize the available body of evidence guiding the management of supratherapeutic concentrations of calcineurin inhibitors (CNI) using cytochrome P450 (CYP450) enzyme inducers. A nondate restricted literature search within MEDLINE, Embase, an...

Edgar, D.G.; Lum, K.R., 1983: Zeeman effect electrothermal atomic absorption spectrophotometry with matrix modification for the determination of arsenic in urine. Arsenic was determined in urine by electrothermal atomic absorption spectrophotometry using Zeeman Effect background correction and after matrix modification with 5% nickel nitrate. Mean recovery of urine samples spiked with 100 micrograms . L-1 d...

Flores, J.C.; Hopp, R., 2015: Intermittence for humans spreading 45,000 years ago: from Eurasia to the Americas. From northeastern Eurasia to the Americas, a three-stage spread of modern humans is considered through large-scale intermittence (exploitation/relocation). Conceptually, this work supports intermittence as a real strategy for colonization of new h...

Nagamori, S.; Vázquez-Ibar, Jé.Luis.; Weinglass, A.B.; Kaback, H.Ronald., 2003: In vitro synthesis of lactose permease to probe the mechanism of membrane insertion and folding. Insertion and folding of polytopic membrane proteins is an important unsolved biological problem. To study this issue, lactose permease, a membrane transport protein from Escherichia coli, is transcribed, translated, and inserted into inside-out m...

Tominaga, M.; Kimura, M.; Igarashi, M.; Eguchi, H.; Igarashi, K.; Abe, T.; Sugiyama, K.; Manaka, H.; Sasaki, H., 1997: Slight but significant improvement of insulin resistance of Wistar fatty rats by treatment with a disaccharidase inhibitor, AO-128. To know whether the insulin resistance is improved by delaying carbohydrate absorption from the small intestine, we studied the effect of a disaccharidase inhibitor, AO-128, on insulin resistance of Wistar fatty rats. Rats were kept on standard la...

Strauss, G.M., 2009: Adjuvant vs neoadjuvant chemotherapy in resectable NSCLC: is that the real question?. Oncology 23(6): 534-6, 538

Jacobsson, G.; Piehl, F.; Meister, B., 1996: Differential regulation of VAMP-1 and VAMP-2 gene expression in spinal motoneurons after axotomy. Society for Neuroscience Abstracts 22(1-3): 1844