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Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells


, : Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. Journal of Experimental Medicine 193(2): 219-231

Inflammation likely has a role in the early genesis of certain malignancies. Interleukin (IL)-15, a proinflammatory cytokine and growth factor, is required for lymphocyte homeostasis. Intriguingly, the expression of IL-15 protein is tightly controlled by multiple posttranscriptional mechanisms. Here, we engineered a transgenic mouse to overexpress IL-15 by eliminating these posttranscriptional checkpoints. IL-15 transgenic mice have early expansions in natural killer (NK) and CD8+ T lymphocytes. Later, these mice develop fatal lymphocytic leukemia with a T-NK phenotype. These data provide novel evidence that leukemia, like certain other cancers, can arise as the result of chronic stimulation by a proinflammatory cytokine.

US$19.90

PMID: 11208862

DOI: 10.1084/jem.193.2.219


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Zaehle, T.; Sandmann, P.; Thorne, J.D.; Jäncke, L.; Herrmann, C.S., 2011: Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence. Transcranial direct current stimulation (tDCS) is a technique that can systematically modify behaviour by inducing changes in the underlying brain function. In order to better understand the neuromodulatory effect of tDCS, the present study examin...

Guglielmo, P.; Stagno, F.; Consoli, U.; Fiumara, P.; Parisi, G.; Privitera, A.; Pelliccia, A.; Pavone, B.; Giustolisi, R., 1998: Spontaneous apoptosis is correlated to PGP-170 functional activity in early chronic lymphocytic leukemia. Blood 92(10 SUPPL 1 PART 1-2): 246B, Nov 15

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Sullivan D.; Yue D.; Capogreco C.; Mclennan S.; Nicks J.; Cooney G.; Turtle J.; Hensley W., 1988: Effects of dietary omega 3 fatty acid on membrane composition and glycemic control in animal models of type i and type ii diabetes. Diabetes Research & Clinical Practice 5(SUPPL 1): S15

Hans, P.; Coussaert, E.; Cantraine, F.; Pieron, F.; Dewandre, P.Y.; d'Hollander, A.; Lamy, M., 1997: Predictive accuracy of continuous propofol infusions in neurosurgical patients: comparison of pharmacokinetic models. The performance of 10 pharmacokinetic models in predicting blood propofol concentrations was evaluated in patients during neurosurgical anesthesia. Eight patients-ASA category I or II, aged 49 +/- 18-years, weighing 71 +/- 20 kg, and scheduled for...

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