+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Filarial infections increase susceptibility to human immunodeficiency virus infection in peripheral blood mononuclear cells in vitro

, : Filarial infections increase susceptibility to human immunodeficiency virus infection in peripheral blood mononuclear cells in vitro. Journal of Infectious Diseases 182(6): 1804-1808

Because helminth infections and human immunodeficiency virus (HIV) coexist in areas where the spread of AIDS is most dramatic, their in vitro interaction was explored. Cryo-preserved peripheral blood mononuclear cells (PBMC) from patients with filarial infections (n = 24) and from unexposed control subjects (n = 12) were depleted of CD8 T cells and were infected with macrophage (M)- and T cell-tropic viruses. A trend toward increased HIV replication in PBMC from filaria-infected patients was observed. Furthermore, PBMC from 6 filaria-infected patients before antifilarial treatment were significantly more susceptible to replication of M-tropic virus than their posttreatment PBMC (P = .03). No intergroup differences were found in the surface expression of HLA-DR, CD25, CCR5, CXCR4, CCR3 on CD4 T cells, or monocytes before infection. PBMC from filaria-infected patients produced less RANTES (P = .02) but more intracellular interleukin-4 than those of control subjects. Thus, PBMC from persons with filarial infections appear to have enhanced susceptibility to HIV-1 infection mediated by an undetermined mechanism.


PMID: 11069260

DOI: 10.1086/317623

Other references

Nosher, J.L.; Siegel, R.L.; Bodner, L.J., 1999: Access to occluded infrainguinal bypass grafts with a loopsnare. Thrombolysis for the treatment of occluded bypass grafts is used in selected clinical circumstances. Unfortunately, a minority of these procedures are technical failures because of the inability to access the occluded graft. We describe a techniqu...

Aditya, G.; Bhattacharyya, S.; Kundu, N.; Kar, P.-Kumar; Saha, G.-Kumar, 2007: Predatory efficiency of the sewage drain nhabiting larvae of Toxorhynchites splendens Wiedemann on Culex quinquefasciatus Say and Armigeres subalbatus (Coquillett) larvae. The rate of predation by stage IV instar Toxorhynchites splendens larvae on the equivalent instar stage larvae of Culex quinquefasciatus and Armigeres subalbatus, co-occurring in sewage drains, were noted for a period of three consecutive days in...

Vigneri, R.; Frasca, F.; Sciacca, L.; Vigneri, P.; Frittitta, L., 2009: Re: Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women. Journal of the National Cancer Institute 101(14): 1030-1; Author Reply 1031-2

Fischer, A., 1961: Experimental results with a new herbicide for beets. The herbicide is 1-phenyl-4-amino-5-chloro-pyridazone-6 (PCA). Its solubility in water is 0.03% at 20 degrees C and 3.54% in methanol. In trials using a light, sandy loam soil, the persistance of PCA was similar to that of OMU and less than that o...

Chu, D.C.; Penney, J.B.; Young, A.B., 1987: Quantitative autoradiography of hippocampal GABAB and GABAA receptor changes in Alzheimer's disease. GABAB and GABAA receptors were examined by quantitative [3H]GABA autoradiography in postmortem human hippocampus from 6 histopathologically verified cases of dementia of the Alzheimer type (DAT) and 6 normal controls. Significant decrements in the...

Weiss, H.B., 1920: The contents of our entomological journals during 1919. Canadian Entomologist, 52 169-173

Gorbea, C.; Pratt, G.; Ustrell, Vça.; Bell, R.; Sahasrabudhe, S.; Hughes, R.E.; Rechsteiner, M., 2010: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. Ecm29 is a 200-kDa HEAT repeat protein that binds the 26 S proteasome. Genome-wide two-hybrid screens and mass spectrometry have identified molecular motors, endosomal components, and ubiquitin-proteasome factors as Ecm29-interacting proteins. The...

Foster, J.S.; Kolenbrander, P.E., 2003: Spatial organization of oral bacteria in biofilm communities. Over 500 different species of bacteria exist within the human oral cavity. Understanding the spatial organization of these multi-species communities may provide insight into the mechanisms by which these organisms initiate biofilm formation. To mo...

Naumkin A.N., 1996: About probable temporal changes of post-folding tectonic stresses in western Ural (Kozhim River). Moscow University Geology Bulletin: , Pages 73-76. 1996.

Wang, J.; Gillaspie, C.; Kunadharaju, R.; Talmon, G.A.; Enke, C., 2011: Sarcomatoid Urothelial Carcinoma: A Single Cancer Center Experience. Sarcomatoid bladder cancer is a rare and aggressive variant of urothelial carcinoma. A retrospective review of our experience in managing patients with sarcomatoid bladder cancer (SRBC) between 1997 and 2011 was performed to better define the beha...