geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Heartburn treatment in primary care: randomised, double blind study for 8 weeks


, : Heartburn treatment in primary care: randomised, double blind study for 8 weeks. Bmj 319(7209): 550-553

Objective To compare the effects and tolerability of omeprazole and cisapride with that of placebo for control of heartburn in primary care patients. Design Randomised, double blind, placebo controlled study. Setting 65 primary care practices in Norway. Participants 483 untreated patients with complaints of heartburn gtoreq3 days a week, with at most grade 1 reflux oesophagitis. Interventions Omeprazole 20 mg once daily, cisapride 20 mg twice daily, or placebo for 8 weeks. Main outcome measures Adequate control of heartburn, defined as ltoreq1 day of the past 7 days with no more than mild heartburn, after 4 weeks of treatment. Results In the all patients treated analysis, adequate control of heartburn was achieved in 71% of patients taking omeprazole, 22% taking cisapride, and 18% taking placebo after 4 weeks of treatment (omeprazole v cisapride and placebo, P<0.0001; cisapride v placebo, non-significant). Results were comparable in patients with or without reflux oesophagitis. In patients treated with omeprazole only, symptom control was achieved significantly more often in patients positive for Helicobacter pylori. Antacid use was 2-3 times greater in patients taking cisapride or placebo than in those taking omeprazole. Relief of non-reflux symptoms did not significantly differ between the three groups. Significantly more patients taking cisapride reported adverse events than those taking omeprazole or placebo. Conclusions Omeprazole 20 mg once daily was highly effective in relieving heartburn whereas cisapride 20 mg twice daily was not significantly more effective than placebo.

US$19.90

PMID: 10463897

DOI: 10.1136/bmj.319.7209.550


Other references

Qiu, J.; Makishima, A., 2005: Rare-earth containing nanocrystal precipitation and up-conversion luminescence in oxyfluoride glasses. Rare-earth ion doped oxyfluoride glass with a composition of 25SiO2 x 5GeO2 x 15AIO1.5 x 40PbF2 x 10PbO x (4.9 - x)GdF3 x 0.1HoF3 x xYbF3 (x = 0, 0.1,0.2, 0.5,1,2, 3, and 4) in molar ratio was developed. When the oxyfluoride glasses are heat-treat...

Threadgill G.J.; Arnstein H.R.V., 1984: Nonhistone proteins of developing mammalian erythroid cells. Anemic rabbit bone marrow cells, labeled with [35S]methionine, were separated at unit gravity. Chromatin was isolated from these cells and proteins were separated from DNA, using urea/salt extraction. Two-dimensional gel electrophoresis of the non...

Balan Menon, P.K., 1964: Revision of nomenclature and classification. Malayan Forest 27(1): 18-21

Veltman, G.A.M.; Van-Veen, S.; Kluin-Nelemans, J.C.; Bruijn, J.A.; Van-Es, L.A., 1997: Renal disease in Waldenstrom's macroglobulinaemia. Nephrology Dialysis Transplantation 12(6): 1256-1259

Jirou Najou, J.L.; Cousty, E.; Chout, R.; Dyck, J.L.; Chevalier, P.; Azaloux, H.; Witte, J.; Fortier, G.; Delpeuch, F., 1985: Malnutrition and anaemia in children in hospital in Martinique. All 100 children from 6 months to 6 years old admitted to a hospital in Martinique during 5 months, mainly with infections and seldom for nutritional reasons, were assessed. Weight deficit in relation to height and anaemia on the basis of haemoglo...

Allen, A.A., 1999: Catoptria falsella in south-east London. Entomologist's Record & Journal of Variation 111(6): 289, Nov -Dec

Kok-Jensen, A., 1979: Combined inhalation of salbutamol and ipratropin in chronic bronchial obstruction. Ugeskrift for Laeger 141(30): 2039-2041

Lemos, J.C.; Roth, C.A.; Messinger, D.I.; Gill, H.K.; Phillips, P.E.M.; Chavkin, C., 2012: Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism. Repeated stress releases dynorphins and causes subsequent activation of κ-opioid receptors (KORs) in limbic brain regions. The serotonergic dorsal raphe nucleus (DRN) has previously been found to be an important site of action for the dysphoric e...

Smith, S.M.; Li, X.; Markevitch, A.; Romanov, D.; Levis, R.J.; Schlegel, H.Bernhard., 2007: Numerical simulation of nonadiabatic electron excitation in the strong-field regime. 3. Polyacene neutrals and cations. The electron optical response for a series of linear polyacenes and their molecular ions (mono and dications) in strong laser fields was studied using time-dependent Hartree-Fock theory. The interactions of benzene, naphthalene, anthracene, and te...

Reis, G.Msm.; Lau, O.Cf.; Samarawickrama, C.; Heydon, P.; Goldberg, I., 2015: Utility of ultrasound biomicroscopy in the diagnosis of topiramate-associated ciliochoroidal effusions causing bilateral acute angle closure. Clinical & Experimental Ophthalmology 42(5): 500-501