+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Heme oxygenase-1 modulates fetal growth in the rat

, : Heme oxygenase-1 modulates fetal growth in the rat. Laboratory Investigation 82(6): 687-692, June

Intrauterine growth restriction is associated with increased perinatal morbidity and mortality as well as with lifelong cardiovascular and metabolic complications. Deficiency of heme oxygenase 1 (HO-1) is associated with growth restriction in mice and in humans, suggesting a role for HO-1 in fetal growth and maintenance of pregnancy. We hypothesized that modulation of HO-1 in the pregnant rat would alter fetal growth. In pregnant dams, placental HO activity was significantly inhibited with zinc deuteroporphyrin IX 2,4 bis glycol, and HO-1 protein was increased by transducing adenoviral human HO-1. Inhibition of HO-1 by zinc deuteroporphyrin IX 2,4 bis glycol resulted in a significant decrease in pup size, whereas transfection with hHO-1 resulted in increased pup size. Furthermore, the expression of IGF binding protein-1 and its receptor paralleled the expression of HO-1 in the placenta and were significantly modulated by modification of HO-1 along with the expression of vascular endothelial growth factor. These observations demonstrate that HO-1 modulates fetal growth by its effects on placental growth factors.


PMID: 12065678

DOI: 10.1097/01.lab.0000017167.26718.f2

Other references

Swanston, Dn, 1980: Influence of forest and rangeland management on anadromous fish habitat in western North America. Impacts of natural events. USDA Forest Service general technical report PNW United States Pacific Northwest Forest and Range Experiment Station: 80 (104)

Martin, R.J.; Wilcox, J.R., 1973: Heritability of lowest pod height in soybeans. High-pod determinate strains of Glycine max were crossed with indeterminate varieties with normal pod bearing. Heritability estimates for lowest pod height in two crosses were slightly greater than those for seed yield and seed size in the F2 gene...

Kolkmann, F.W.; Völzke, E., 1967: On the spongy dystrophies of the nervous system in early childhood. II. Focally disseminated forms with preference of the brain stem (infantile Wernicke syndrome and subacute necrotizing encephalopathy). Zeitschrift für Kinderheilkunde 98(4): 287-306

Belser, U.C.; Hannam, A.G., 1986: The contribution of the deep fibers of the masseter muscle to selected tooth-clenching and chewing tasks. Anatomically, the human masseter muscle consists of at least two portions (pars superficialis, pars profunda) with distinctly different fiber directions. The purpose of this study was to describe functional behavior in the deep fibers of the masse...

Allen, J.P.; Cook, D.M.; Olsen, J., 1975: Effect of insulin induced hypoglycemia on ACTH, cortisol, and growth hormone release in man. Military Medicine 140(12): 837-840

Lapshina, I.G., 1969: Treatment of diphyllobothriasis using bithionol with phenasal. A study of combined use of bithionol and phenasal to test their ability to control diphyllobothriasis, in 49 patients of both sexes aged 5 to 72 years, is described with reference to the length of symptoms and the presence or absence of underlying...

Fraaije, R.H.B., 2002: The first record of albuneid crabs (Crustacea, Decapoda) from the Cretaceous. A recently collected new member of the Albuneidae from the type Maastrichtian of the Netherlands extends the range of the family from the Eocene down to the Cretaceous. Praealbunea rickorum new genus and species is yet another example of the major...

Reed, J.K.; Weaver, D.C.; Pomponi, S.A., 2006: Habitat and fauna of deep-water Lophelia pertusa coral reefs off the southeastern U.S.: Blake Plateau, Straits of Florida, and Gulf of Mexico. Expeditions from 1999 to 2004 for biomedical research explored various deep-sea coral ecosystems (DSCE) off the southeastern U.S. (Blake Plateau, Straits of Florida, and eastern Gulf of Mexico). Habitat and benthos were documented from 57 dives wi...

Centaro, A., 1967: On the subject of radical vulvectomy. Minerva Ginecologica 19(16): 824-826

Lou, J.; Si, H.; Chen, Y.; Sun, X.; Zhang, H.; Niu, A.; Hu, C., 2014: Correlation between KLK6 expression and the clinicopathological features of glioma. We measured the impact of changing KLK6 expression levels on the pathological grade of gliomas and on proliferation rate, cell cycle progression, and apoptosis in the U251 glioblastoma cell line. The expression of KLK6 in 35 brain glioma tissues a...