+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hepatocyte growth factor enhances MMP activity in human endothelial cells

, : Hepatocyte growth factor enhances MMP activity in human endothelial cells. Biochemical and Biophysical Research Communications 272(3): 900-905

Scatter factor (SF) or hepatocyte growth factor (HGF) has been identified as an angiogenic factor. Angiogenesis requires not only tube formation but also invasion of pericytes and extracellular matrix (ECM) remodeling to promote new vessel stabilization. In the current study, the effect of SF/HGF on endothelial cell (EC) production of matrix metalloproteinases (MMPs) was explored. We showed that SF/HGF enhanced MT1-MMP synthesis and induced MMP-2 activation in two human EC lines: dermal microvessel EC and coronary arterial EC. Furthermore, SF/HGF accelerated EC invasion into matrix, an activity that could be inhibited by a MMP inhibitor. We also demonstrated that the MAP kinase cascade is critical in signal transduction pathway from SF/HGF stimulation to MT1-MMP up-regulation. The current study indicates that MMP activation is a novel effect of SF/HGF on ECs.


PMID: 10860849

DOI: 10.1006/bbrc.2000.2852

Other references

Villanti P.; Calabro R.; Valora N.; Moscatello B.; Coppolino L., 1969: Observations on the late evolution in a group of cases of decubital angor associated with other types of steno cardia. Bollettino della Societa Italiana di Cardiologia 14(6): 904-909

Kolpakov, F.I., 1964: A Histochemical Method Of Determination Of Nickel In Body Tissues And Toxicity Of Its Transdermal Administration. Farmakologiia i Toksikologiia 27: 367-369

Yiemwattana, I.; Kaomongkolgit, R., 2014: Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts. This study aims to investigate the effect of alpha-mangostin on interleukin (IL)-6 and IL-8 expression in human gingival fibroblasts (HGFs). HGFs were challenged with Porphyromonas gingivalis LPS and then treated with various concentrations of alp...

Anonymous, 2006: Study: quality improving at a modest pace. Study shows 10.2% improvements in patient safety core measures. Worst performer among 44 core measures was ED patients who left without being treated. Hospital procedures generally performed better than prevention in chronic disease states.

Anonymous, 1987: Products & materials. Science 238(4828): 836-836

Mckean, I., 1952: Faculty work conferences improved our curriculum. American Journal of Nursing 52(10): 1254-1255

Small, H.G.J.; Mccants, C.B., 1962: Residual arsenic in soils & concentration in tobacco. In flue-cured tobacco-growing areas in North Carolina, the As content was 1-5 ppm with an average of 2.8 ppm. Since the reported As content of virgin soils is approximately 4 ppm, the use of arsenicals on tobacco has had no appreciable influence o...

Oyama K.; Dirzo R., 1987: The interaction between the dioecious palm chamaedorea tepejilote and calyptocephala marginipennis coleoptera chrysomelidae a case of herbivory differentiated on the basis of the sex of the plant. Revista de Biologia Tropical 35(SUPPL 1): 229-230

Fortune Hopkins, HC., 1988: Grey imperial pigeon near Karawari Lodge, east Sepik Province. Muruk, 31: 6

Owen, A.M.; Menon, D.K.; Williams, E.J.; Minhas, P.S.; Johnsrude, I.S.; Scott, S.K.; Allen, C.M.C.; Boniface, S.J.; Kendall, I.V.; Downey, S.P.M.J.; Antoun, N.; Clark, J.C.; Manly, T.; Pickard, J.D., 1999: Detecting residual cognitive function in persistent vegetative state using functional neuroimaging. Society for Neuroscience Abstracts 25(1-2): 1091