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Hexarelin-induced growth hormone response in short stature. Comparison with growth hormone-releasing hormone plus pyridostigmine and arginine plus estrogen


, : Hexarelin-induced growth hormone response in short stature. Comparison with growth hormone-releasing hormone plus pyridostigmine and arginine plus estrogen. Journal of Endocrinological Investigation 22(5): 360-368

Hexarelin (HEX) is a synthetic hexapeptide with strong GH-stimulating activity. We evaluated GH response (expressed as maximum value after stimulus (Cmax) and as area under the curve (AUC)) to HEX at the doses of 1 mug/kg iv (HEX 1) and 2 mug/kg iv (HEX 2), in comparison with the responses to GHRH (1 mug/kg iv) + pyridostigmine (PD, 60 mg po) and to arginine (ARG, 0.5 mg/kg iv) + ethinylestradiol (EE, 1 mg/day po for 3 days before the stimulation), in 5 subjects with familial short stature (FSS), 11 with constitutional growth delay (CGD), 6 with GH neurosecretory dysfunction (NSD), and 5 with isolated growth hormone deficiency (GHD). Cmax and AUC after HEX 1 were 26.8+-10.5 ng/ml and 1448+-514 ng/min X ml in FSS, 23.6+-14.4 ng/ml and 1146+-750 ng/min X ml in CGD, 36.9+-21.5 ng/ml and 2048+-1288 ng/min X ml in NSD, 9.4+-5.8 ng/ml and 498+-200 ng/min X ml in GHD (Cmax and AUC in FSS and CGD, p<0.05 vs GHD). Cmax and AUC after HEX 2 were 37.7+-16 ng/ml and 1979+-888 ng/min X ml in FSS, 32.5+-16.2 ng/ml and 1613+-237 ng/min X ml in CGD, 39.7+-20.7 ng/ml and 2366+-1569 ng/min xml in NSD, 13.4+-4.2 ng/ml and 645+-293 ng/min X ml in GHD (Cmax in FSS, CGD and NSD p<0.01 vs GHD; AUC in NSD, p<05 vs GHD). Cmax and AUC after GHRH+-PD were 46.6+-8.8. ng/ml and 3294+-1031 ng/min X ml in FSS, 25.9+-11.2 ng/ml and 1464+-735 ng/min X ml in CGD, 38.8+-21.7 ng/ml and 2428+-1399 ng/min X ml in NSD, 8.4+-6.2 ng/ml and 685+-572 ng/min X ml in GHD (Cmax and AUC in FSS, p<0.001 vs CGD and GHD; Cmax in CGD and NSD, p<0.001 vs GHD). Cmax and AUC after ARG+EE were 21.3+-4.2 ng/ml and 1432+-514 ng/min X ml in FSS, 14.8+-10 ng/ml and 805+-489 ng/min X ml in CGD, 22.2+-12.8 ng/ml and 1199+-309 ng/min X ml in NSD, 4.6+-2.5 ng/ml and 247+-191 ng/min X ml in GHD (Cmax and AUC in FSS, CGD and NSD, p<0.01 vs GHD). Specificity was 62% for HEX 1 and 75% for HEX 2, GHRH+PD and ARG+EE. From a diagnostic point of view, HEX 1 + HEX 2 was the association with the largest percentage of false positives (20% in FSS, 27% in CGD and 33% in NSD), HEX 1+GHRH+PD resulted in 9% in CGD, while the combined use of HEX 1 or HEX 2 with GHRH+PD or ARG+EE and of GHRH+PD with ARG+EE did not show false positive responses. In conclusion: 1) the most effective dose of HEX was 2 mug/kg iv; 2) HEX did not show more specificity than GHRH+PD and ARG+EE; 3) the association of GHRH+PD with ARG+EE could yield the best results at lower costs, confirming these tests as first-line tools in evaluating GH secretion.

US$19.90

PMID: 10401710

DOI: 10.1007/BF03343574


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Jimenez-Cruz, C.Andres.; Garcia, A.E., 2013: Reconstructing the Most Probable Folding Transition Path from Replica Exchange Molecular Dynamics Simulations. The characterization of transition pathways between long-lived states, and the identification of the corresponding transition state ensembles are useful tools in the study of rare events such as protein folding. In this work we demonstrate how the...

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Burns, Marie E., 2000: Deactivation mechanisms of retinal photoreceptors A physiological study of transgenic mouse rods. Biophysical Journal 78(1 Part 2): 387A, Jan

Fujita, M.; Takami, M.; Usugane, M.; Nampei, S.; Taguchi, T., 1979: Enhancement of gastric carcinogenesis in dogs given N-methyl-N'-nitro-N-nitrosoguanidine following vagotomy. Cancer Research 39(3): 811-816

Ouzzine, M.; Gulberti, S.; Ramalanjaona, N.; Magdalou, J.; Fournel-Gigleux, S., 2014: The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication. UDP-glucuronosyltransferases (UGTs) form a multigenic family of membrane-bound enzymes expressed in various tissues, including brain. They catalyze the formation of β-D-glucuronides from structurally unrelated substances (drugs, other xenobiotics...

Nobili, R.; Luporini, P., 1967: Maintenance of heterozygosity at the mt locus after autogamy in Euplotes minuta (Ciliata Hypotrichida). Genetical Research 10(1): 35-43

Schuler, T.H.; Potting, R.P.J.; Clark, A.J.; Denholm, I.; Poppy, G.M., 2003: Tritrophic interactions between a B t plant, the diamondback moth and a braconid endoparasitoid. Journal of Insect Science (Tucson) 3(33 Cited October 24, ): 22, October 16

Finlayson B.J.; Ashuckian S.H., 1979: Safe zinc and copper levels from the spring creek drainage for steelhead trout in the upper sacramento river california. Acid mine discharges in the Spring Creek drainage, collecting behind the Spring Creek Diversion Dam, contribute large quantities of toxic Zn and Cu to the upper Sacramento River, California, USA. Ratios of Cu:Zn for the Spring Creek Diversion Dam...

Watanabe, H.; Aihara, T.; Tsukada, M., 2006: Phase shift of subthreshold theta oscillation hippocampal CA1 pyramidal by excitatory synaptic inputs. Hippocampal CA1 neurons receive multiple rhythmical inputs with relatively independent phases during theta activity. It, however, remains to be determined how these multiple rhythmical inputs affect oscillation properties in membrane potential of...