geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

IGF1 activates PKC alpha-dependent protein synthesis in adult rat cardiomocytes


, : IGF1 activates PKC alpha-dependent protein synthesis in adult rat cardiomocytes. Molecular Cell Biology Research Communications 4(3): 166-171, September

Acute exposure to interleukin 1 beta (IL1beta) or insulin-like growth factor 1 (IGF1) promoted the translocation of PKC alpha from the cytosol to the membrane of adult rat cardiomyocytes. Western analysis demonstrated that membranal localization of PKC alpha was increased from 23% in the control to 49% after exposure to IGF1, and it was increased to 42% after exposure to IL1beta. Activation of Erk1/Erk2 by IGF1 and ILbeta was studied using a phosphorylation-specific antibody. IGF1-induced activation of p44/p42 MAP kinase was blocked by preincubation with the PKC inhibitors, bisindolylmaleimide and Go6976, as well as the tyrosine kinase inhibitor, genistein. IGF1 increased the rate of protein synthesis, indicated by the increase in L-(14C(U)) phenylalanine incorporation over time, and this effect was inhibited by Go6976.

US$29.90


Other references

Ben Jaafar, E., 1992: An attempt to establish a typology of urbanization trends in Tunisia. This is an analysis of trends in urbanization in Tunisia since 1936 and is based on official data. The author examines differences in the rate of growth among urban areas of different sizes as well as regional differences.

Furowicz, A.J.; Czernomysy Furowicz, D., 1996: Efficacy of 'Biostymina' in the treatment of bronchopneumonia in calves. Biostymina is a natural immunomodulator based on Aloe arborescens aqueous extract licensed for the treatment of animals in Poland. In studies of 20 Polish Lowland Black-and-White calves, 4- to 5-month-old, with chronic bronchopneumonia, 10 calves...

Fletcher, J.; Martinez, G., 1994: An eye-movement analysis of the effects of scotopic sensitivity correction on parsing and comprehension. Does scotopic sensitivity correction enhance parsing and, thus, comprehension? Twenty-two readers with scotopic sensitivity (mean age = 20.3 yrs.; 40.9% male) parsed sentences under scotopic correction and control conditions. Measures included eye...

Remy, P., 1928: Is the hamster established in Champagne. Compt Rend Som Soc Biogeogr 30: 40-43

Kuchenbecker, J.; Lindner, H., 2005: Visual function tests on the Internet--sense or nonsense?. The quantitative capability of the visual system can be tested using graphic presentations with defined size, form and color. For presentations, a chart projector or monitor can be used. Today, the number of visual function tests on the Internet i...

Syokyu, N.; Fujimoto, J.; Hori, I.; Ohashi, H., 1976: Cultivation and breeding of oenothera plant part 7 effect of selection on the growth development and seed components of oenothera biennis. The effect of the individual selection for seed weight on the growth, development and seed components of O. biennis was studied. The effects of selection on the yield of seed varied with different strains. The positive results of selection were ob...

Fukushima, D.K.; Bradlow, H.L.on; Yamauchi, T.; Yagi, A.; Koerner, D., 1968: Fate of 4 -hydrogen in 5-androstene-3,17-dione on isomerization with mammalian enzyme preparation. The isomerization of [DELTA]3-androstene-3,17-dione-4-14C, 4[beta]-% to [DELTA]4-androstenedione was studied with beef adrenal microsomes and rat liver 100, 000 x g supernatant preparations. A 73 and 45% Loss of the tritium respectively was observ...

Ali Zade M.A.; Aliev R.T., 1972: Dna content in the somatic cell and chromosome in poly ploid forms of wheat. Doklady Biological Sciences 203(1-6): 205-206

Wegener, J.; Tareilus, E.B.eer, H., 1992: Characterization of calcium-dependent potassium channels in antennal receptor neurones of Locusta migratoria. Antennal receptor neurones from Locusta migratoria were identified by their bipolar morphology and their immunoreactivity with anti-horseradish-peroxidase antibodies. Using patch clamp techniques, an ion channel displaying a high conductance (180...

D.G.ovanni Christian; Disnar Jean Robert; Bichet Vincent; Campy Michael, 2000: Seasonal variations and threshold effects of organic detrital sedimentation in lakes; imbalances between organic records and climatic fluctuations, Chaillexon Basin, Doubs, France. Optical analysis (palynofacies) of the organic matter (OM), occurring in various compartments (soils, bedrock formations, lacustrine chalks) of the lacustrine basin of Chaillexon (Doubs, France) has led to the definition of organic markers. Their...