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Imaging of adenosine bolus transit following intravenous administration: insights into antiarrhythmic efficacy


, : Imaging of adenosine bolus transit following intravenous administration: insights into antiarrhythmic efficacy. Heart 82(2): 163-169

Objective-To study the effects of the site of intravenous injection of adenosine and to assess the site of action of adenosine in the heart by correlating cardiac effects with bolus transit. Methods-Ten patients undergoing routine technetium (Tc-99m) gated blood pool ventriculography consented to the coadministration of intravenous adenosine. The dose of adenosine required to produce heart block during sinus rhythm was determined following antecubital vein administration. This dose (6-18 mg) was mixed with Tc-99m and given first into the same antecubital vein (proximal injection) and then repeated into a hand vein (distal injection). The ECG was recorded and the transit of the bolus was imaged using a gamma camera. Results-Heart block occurred in all 10 patients (second degree in seven, first degree in three) at (mean (SEM)) 17.5 (1.0) seconds after the proximal injection of adenosine. Distal injection produced heart block in six patients (second degree in two, first degree in four)at 21.9 (4.4) seconds (p < 0.01). In eight of 10 patients the electrophysiological effects were less with distal injection. The onset of heart block was close to the time of peak bolus Tc-99m activity in the left ventricle. Peak bolus activity was delayed (by about three seconds) and the duration of bolus activity in the left ventricle was increased with distal injection compared with proximal injection, at 17.2 (4.2) v 9.2 (3.1) seconds, p < 0.01. Conclusions-The lesser electrophysiological effects of adenosine following distal intravenous injections were associated with delay in transit time and dispersion of the bolus. The correlation of adenosine induced heart block with bolus activity in the left heart indicated dependence on coronary arterial delivery of adenosine to the atrioventricular node.

US$19.90

PMID: 10409529

DOI: 10.1136/hrt.82.2.163


Other references

Leitermann, F.; Syldatk, C.; Hausmann, R., 2008: Fast quantitative determination of microbial rhamnolipids from cultivation broths by ATR-FTIR Spectroscopy. Vibrational spectroscopic techniques are becoming increasingly important and popular because they have the potential to provide rapid and convenient solutions to routine analytical problems. Using these techniques, a variety of substances can be c...

Anonymous, 1982: Education workshop on health service assessment and planning. Barbados 9-13 November 1981. Educacion Medica Y Salud 16(2): 214-225

Koupparis, A.M.; Kokkinos, V.; Kostopoulos, G.K., 2013: Spindle power is not affected after spontaneous K-complexes during human NREM sleep. K-complexes and sleep spindles often grouped together characterize the second stage of NREM sleep and interest has been raised on a possible interaction of their underlying mechanisms. The reported inhibition of spindles power for about 15 seconds...

Labuc G.E.; Blunck J.M., 1979: Metabolic activation of the hepato carcinogen 3 methyl 4 dimethylaminoazo benzene by a rat liver cell free system evidence suggesting the formation of at least 2 electrophilic metabolites. A cell-free system obtained from rat liver is described which catalyzes the covalent binding of [3H]-3'-methyl-4-dimethylaminoazobenzene (3'MeDAB) to yeast RNA and endogenous tissue protein. The binding to yeast RNA requires the presence...

Lohrmann, H.P., 1984: The problem of permanent bone marrow damage after cytotoxic drug treatment. The majority of cytotoxic drugs exert a dose-dependent injury to the hemopoietic bone marrow. In experimental systems, two different types of damage to the hemopoietic stem cell compartments have been demonstrated to occur following cytotoxic drug...

Cayouette, R.; Brassard, F.L., 1960: The presence of poison ivy (R. radicans) in the Saguenay region. A brief account of the discovery of 4 small colonies of R. radicans var. Rydbergii in the Saguenay region.

Lee, C.L.; An-Tze, S.; Kwei, Y., 1964: L. Studies on the growth of excised stem tips of Stachys sieboldii. II. The effect of several growth-promoting substances upon the morphological differentiation of stem tips. Of the various substances added to the basic tissue-culture media IAA and gibberellin at 0.5 p.p.m., bee royal jelly at 100 p.p.m. and adenine at 1 and 10 p.p.m. had the most effect upon growth. At low concentrations the development of the adventi...

Sapra, Val T.Reviewer, 1998: Triticale (book review). Crop Science 38(4): 16

Li, X-C.; Ma, Y-F.; Wang, X-H., 2006: Role of NF-kappaB as effector of IPC in donor livers before liver transplantation in rats. The objective of this study was to investigate the effect of ischemic preconditioning (IPC) on NF-kappaB activity during reperfusion early after liver transplantation in rats. Male Sprague-Dawley (SD) rats were used as donors and recipients of ort...

Turner, W.Rwick, M.; Doniach, D., 1965: Auto-Antibody Studies In Interstitial Pulmonary Fibrosis. Auto-antibody studies were performed in 48 patients with interstitial pulmonary fibrosis, of whom 14 also had rheumatoid arthritis. Positive results in one or more tests were obtained in 32, most of the antibodies being of non-organ-specific natur...