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Immunity in ampicillin administration against the background of immunosuppression


, : Immunity in ampicillin administration against the background of immunosuppression. Eksperimental'naya i Klinicheskaya Farmakologiya 61(6): 39-41, Nov -Dec

The effect of 50 ml and 100 mg/kg doses of ampicillin, immunocompromised by cyclophan and azathioprine, on immunity of intact mice was studied. Ampicillin did not change the number of antibody-forming cells (AFC) and delayed hypersensitivity (DHS) in immunosuppression. It inhibited spontaneous oxidant metabolism of neutrophils and macrophages against the background of azathioprine. The therapeutic effect of ampicillin was maintained under such conditions. In intact animals the antibiotic did not change the number of AFC, increased DHS expression, and reduced the spontaneous index of macrophage activation in the nitroblue tetrazolium test.

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