+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunocytochemical demonstration of the equilibrative nucleoside transporter rENT1 in rat sinoatrial node

, : Immunocytochemical demonstration of the equilibrative nucleoside transporter rENT1 in rat sinoatrial node. Journal of Histochemistry and Cytochemistry 50(3): 305-309

Adenosine exerts multiple receptor-mediated effects in the heart, including a negative chronotropic effect on the sinoatrial node. The aim of this study was to investigate the distribution of the equilibrative nucleoside transporter rENT1 in rat sinoatrial node and atrial muscle. Immunocytochemistry and/or immunoblotting revealed abundant expression of this protein in plasma membranes of sinoatrial node and in atrial and ventricular cells. Because rENT1-mediated transport is likely to regulate the local concentrations of adenosine in the sinoatrial node and other parts of the heart, it represents a potential pharmacological target that might be exploited to ameliorate ischemic damage during heart surgery.


PMID: 11850433

DOI: 10.1177/002215540205000302

Other references

Keller, M.B.; Hanks, D.L., 1994: Psychiatry in the year 2018. Rhode Island Medicine 77(6): 170-172

Gouli,V.V.; Provost,C.; Parker,B.L.; Skinner,M.; Gouli,S.Y., 2010: Comparison of two methods for estimation of spray deposits after application of microbial pesticides. The effectiveness of two methods for the determination of deposition of mycopesticides on hemlock trees by spray application was compared. One method employs water and oil sensitive paper cards; the other uses a combination of two adhesive tapes (...

Dale, H.C., 1967: Familiarity and free recall. Quarterly Journal of Experimental Psychology 19(2): 103-108

Butzler, J.P., 1982: Campylobacter Enteritis. Campylobacter jejuni (previously called "related vibrio") has recently become recognized as an important cause of acute diarrhoeal disease in many countries. As with other intestinal pathogens, the clinical picture of C. jejuni infection...

Palmgren, Gorm, 1997: Transgenic plants Environmentally safe factories of the future Metabolic Engineering in Transgenic Plants, Copper Mountain, CO, USA, April 6-11, 1997. Trends in Genetics 13(9): 348

Heran I., 1989: Longevity in captive mammals melursus ursinus hyaena brunnea. Lynx (Prague) 25: 97-98

Kinne, D.W.; Simmons, R.L., 1971: Passive serologic transfer of immunity to skin grafts in allogeneic and isogeneic mice. Review of Surgery 28(1): 68-68

Mallard, Daniel., 2001: A short insight into Fasciolariidae Petit tour chez les Fasciolariidae. Xenophora. Juillet-Aout-Septembre; 95: 11-15

Ziegler P.A., 1979: North Sea exploration. AAPG Bulletin 63(3): 556

Roeseler, S.T.; Wagenmann, M.; Bachert, C., 1996: Prevalence of storage mite sensitisation in urban patients. Journal of Allergy & Clinical Immunology 97(1 PART 3): 226