geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Impact of oral submucous fibrosis on chemotherapy-induced mucositis for head and neck cancer in a geographic area in which betel quid chewing is prevalent


, : Impact of oral submucous fibrosis on chemotherapy-induced mucositis for head and neck cancer in a geographic area in which betel quid chewing is prevalent. American Journal of Clinical Oncology 22(5): 485-488

In Southeast Asia and Taiwan, betel quid chewing is prevalent. Patients with head and neck cancer who chewed betel quid habitually seem to experience more severe chemotherapy-induced mucositis in our clinical practice. To validate this issue, patients with untreated head and neck cancer who received cisplatin (cDDP) plus a 5-fluorouracil (5-FU)-based neoadjuvant chemotherapy were included in this analysis. Information on the consumption of betel quid, tobacco, and alcohol were recorded before chemotherapy. Oral submucous fibrosis (OSF) was diagnosed clinically according to the fibrotic appearance of the mucosa and trismus. Mucositis was scored according to the World Health Organization criteria, and the mucositis score of the first course of chemotherapy was used for analysis. From December 1993 to April 1996, 120 patients were enrolled in this trial. Neither the betel quid chewing nor the cancer of the oral cavity was to be a significant factor for mucositis. However, clinically diagnosed OSF was found to display a significant correlation with more severe mucositis (p = 0.02). We concluded that in betel quid chewing-prevalent areas, OSF was a risk factor of more severe mucositis in head and neck cancer patients treated by CDDP and 5-FU-based regimens.

US$29.90

PMID: 10521064


Other references

Cole J.J.; Caraco N.F.; Likens G.E., 1990: Short range atmospheric transport a significant source of phosphorus to an oligotrophic lake. During summer stratification, particles transported by wind from surrounding forest were a major source of P into Mirror Lake, a small, oligotrophic lake in New Hampshire [USA]. These particles consisted largely of terrestrial insects, insect part...

Taylor, C.M.; Jones, H.C., 1985: The formation of cerebrospinal fluid in two amphibians, Rana catesbeiana and Rana pipiens. The cerebrospinal fluid (CSF) system of two amphibians, Rana catesbeiana and Rana pipiens has been perfused from the lateral ventricle to a site in the subarachnoid space close to the roof of the fourth ventricle. The CSF production rate (Vf) was...

KLAPaLEK.F., 1889: The metamorphoses of Apatoenia muliebris, M'Lach. A chapter in parthenogenesis. Entomologist's Monthly Magazine, XXV 241 & 242

Sliesaravicius, A.; Petraityte, N.; Dastikaite, A., 2004: Ecogeographical distribution and biodiversity of winter vetch (Vicia villosa Roth) in Lithuania. Winter vetch (Vicia villosa) belongs to the element of European flora. It is known as a fodder plant and agrophytocenoses component. In the "Genefund" programme, the vetch has been investigated at the Lithuanian University of Agriculture...

Kritis, A.A.; Argyrokastritis, A.; Moschonas, N.K.; Power, S.; Katrakili, N.; Zannis, V.I.; Cereghini, S.; Talianidis, I., 1996: Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4. Hepatocyte nuclear factor 4 (HNF-4) is an essential positive regulator of a large number of liver-specific genes. We report here the isolation of three HNF-4 isoforms from a human liver cDNA library. hHNF-4A and hHNF-4B, differing by the insertion...

Butcher, R.J.; Akkurt, M.; Jarrahpour, A.; Badrabady, S.Ali.Torabi., 2011: 3-(4-Chloro-phen-oxy)-1-(4-meth-oxy-phen-yl)-4-(4-nitro-phen-yl)azetidin-2-one. In the title compound, C(22)H(17)ClN(2)O(5), the nearly planar four-membered β-lactam ring [maximum deviation of 0.016 (1) for the N atom] makes dihedral angles of 53.07 (9), 73.19 (9) and 6.61 (9)° with the chloro-, nitro- and meth-oxy-...

Jarris, P.E.; Mishra, M., 2014: Making health equity a core part of all public health work. Journal of Public Health Management and Practice 19(3): 278-280

Myartseva S.N., 1981: New parasite species hymenoptera encyrtidae of scale insects and leafhoppers homoptera coccoidea and psylloidea from the turkmen ssr ussr. Four new encyrtid species of the Turkmenistan were described: Aphycis deynauensis and A. slavai, (parasites on Homoptera), and Psyllaephagus turanicus and P. hammadae (parasites on Psylloidea). A species determination table of female Aphycis Mayr...

Morales Aquilera A.; Bryant S.H., 1971: The action of some mono carboxylic aromatic acids on striated muscle fibers. Boletin de Estudios Medicos y Biologicos Universidad Nacional Autonoma de Mexico 27(5): 137-138

Pangrazio, A.; Pusch, M.; Caldana, E.; Frattini, A.; Lanino, E.; Tamhankar, P.M.; Phadke, S.; Lopez, A.Gonzalez.Meneses.; Orchard, P.; Mihci, E.; Abinun, M.; Wright, M.; Vettenranta, K.; Bariae, I.; Melis, D.; Tezcan, I.; Baumann, C.; Locatelli, F.; Zecca, M.; Horwitz, E.; Mansour, L.Sfaihi.Ben.; Van Roij, M.; Vezzoni, P.; Villa, A.; Sobacchi, C., 2010: Molecular and clinical heterogeneity in CLCN7-dependent osteopetrosis: report of 20 novel mutations. The "Osteopetroses" are genetic diseases whose clinical picture is caused by a defect in bone resorption by osteoclasts. Three main forms can be distinguished on the basis of severity, age of onset and means of inheritance: the dominant...