geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Increased immunoexpression of atrial natriuretic peptide in the heart conduction system of the rat after cardiac sympathectomy


, : Increased immunoexpression of atrial natriuretic peptide in the heart conduction system of the rat after cardiac sympathectomy. Journal of Molecular and Cellular Cardiology 30(10): 2047-2057

The present investigation was designed to elucidate which role the sympathetic nerves play in the immunoexpression of atrial natriuretic peptide in the cardiac conduction system of the rat. In order to destroy the cardiac sympathetic nerve terminals, both surgical and chemical sympathectomy were performed. By use of immunohistochemical and radioimmunoassay techniques, the immunoreactivity and level of atrial natriuretic peptide in the conduction system and in the cardiac myocardium were determined. In contrast to the low degree of immunoreaction for atrial natriuretic peptide seen in control rats, the sympathectomized rats exhibited pronounced immunoreactivity for atrial natriuretic peptide in the atrioventricular bundle and bundle branches, which normally have high numbers of sympathetic nerve fibres. On the other hand. in the peripheral parts of the conduction system, where there are ordinarily few sympathetic nerve fibres, the degree of immunoreaction was unchanged. The quantitative measurements also showed that the entire ventricles, including the conduction system, contained increased levels of atrial natriuretic peptide in the treated hearts. The present study shows that destruction of the sympathetic nervous system leads to an increased level of atrial natriuretic peptide in the Purkinje fibres of bundle branches, which thus seem to have a dormant capacity for synthesis of this peptide. The results provide new evidence about the change in atrial natriuretic peptide levels that occurs when sympathetic innervation is altered.

US$19.90

PMID: 9799658

DOI: 10.1006/jmcc.1998.0767


Other references

Vorster, A.A.; Beighton, P.; Ramesar, R.S., 2016: Spondyloepimetaphyseal dysplasia with joint laxity (Beighton type); mutation analysis in eight affected South African families. Spondyloepimetaphyseal dysplasia with joint laxity (SEMD-JL), type 1 is an autosomal recessive disorder which has been identified in more than 30 affected children in the Afrikaans-speaking community of South Africa. Sequencing of B3GALT6 revealed...

Bodkin, G.E., 1919: Report of the Economic Biologist. From mosquito larvae collected in experimental rice plots irrigated with artesian well water the only species bred were Culex atratus, Theo., and Umnotaenia geomeirica, Theo. Provided there is a good supply of running, water, the danger of mosquit...

Sterkers O.; Ferrary E.; Tran B.H.y P., 1990: Production of the inner ear fluids. M-S (Medecine Sciences) 6(8): 755-761

Leyendecker, G.; Wildt, L., 1984: Pulsatile administration of Gn-RH in hypothalamic amenorrhea. The physiological and pathophysiological basis of hypothalamic amenorrhoea are reviewed as well as the clinical results of chronic intermittent (pulsatile) administration of Gn-RH in the treatment of infertility. Hypothalamic amenorrhoea is consid...

Feuls, R.; König, J.; Duda, S.H., 2001: Complete endovascular reconstruction of visceral arteries. Rofo 173(4): 379-380

Borghaei, R.C.; Sinai, R.S.; Mochan, E.; Pease, E.A., 1998: Induction of mitogen-inducible nuclear orphan receptor by interleukin 1 in human synovial and gingival fibroblasts. High levels of interleukin 1 (IL-1) found in inflammatory diseases such as rheumatoid arthritis and periodontitis act on the local fibroblasts, resulting in an altered phenotype characterized by hyperplasia and the production of inflammatory media...

Yassin, T.; Paget, J., 1996: Ward sisters' views of the effect of NHS changes. The role of the ward sister or charge nurse has long been acknowledged as being central to the provision of high-quality patient care. Health service reforms since the 1980s have led to greater managerial responsibility for ward sisters and charge...

Dell, R.K., 1968: Composition and distribution of the New Zealand brachyuran fauna. Transactions of the Royal Society of New Zealand Zoology, 10: 225-240

Cronholm, B.; Ottosson, J.O.; Cronholm, B.; Ottosson, J.O., 1996: Experimental studies of the therapeutic action of electroconvulsive therapy in endogenous depression. The role of the electrical stimulation and of the seizure studied by variation of stimulus intensity and modification by lidocaine of seizure discharge. Three methods of electroconvulsive therapy (ECT) were compared in respect of therapeutic effect in 69 attacks of endogenous depression in 65 patients, not previously treated by ECT during the actual period of illness. The treatments were given und...

Cole, J.M., 1980: Developing effective advisory councils. One of Extension's basic mandates is to help people identify resources and solve their problems. The educational value of its programmes lies in both their content and the process of developing them. Advisory councils reflect a viable method...